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Table 2 Comparison of laboratory parameters between patients with IgG4-ROD and nIgG4-ROD

From: Clinical features and relapse risks of IgG4-related ophthalmic disease: a single-center experience in China

Laboratory parameter IgG4-ROD nIgG4-ROD P value
Low serum C3, n (%) 87(39.7) 51(34.7) 0.330
Low serum C4, n (%) 75(34.7) 44(29.9) 0.340
Hypocomplementemia, n (%) 100(45.9) 63(42.9) 0.570
Elevated ESR, n (%) 94(49.5) 78(55.3) 0.293
Elevated CRP, n (%) 30(16.3) 45(31.9) 0.001*
Elevated globulin, n (%) 54(28.6) 41(29.1) 0.920
Eosinophilia, n (%) 60(27.8) 33(21.6) 0.176
RF+, n (%) 43(20.5) 26(18.7) 0.684
ANA+, n (%) 32(14.3) 25(16.7) 0.542
Elevated IgE, n (%) 178(84.0) 77(71.3) 0.008*
C3 (g/L), mean ± SD 0.852 ± 0.280 0.935 ± 0.319 0.053
C4 (g/L), mean ± SD 0.184 ± 0.095 0.200 ± 0.093 0.115
ESR (mm/h), median (IQR) 18.5(8.0–40.0) 23.5(10.0–59.0) 0.058
CRP (mg/L), median (IQR) 2.24(1.00–4.70) 3.05(1.26–12.45) 0.004*
Globulin (g/L), median (IQR) 33.7(29.7–41.5) 35.4(29.8–41.5) 0.808
Serum IgG4 (mg/dl), median (IQR) 983(409–1838) 523(225–1370) < 0.001*
Serum IgG (g/L), median (IQR) 17.5(14.3–23.2) 17.2(14.1–22.0) 0.609
IgG4/IgG, median (IQR) 0.529(0.272–0.879) 0.294(0.143–0.629) < 0.001*
Serum IgE (IU/ml), median (IQR) 339.7(160.8–847.6) 259.4(83.1–653.3) 0.022*
  1. SD standard deviation, IQR interquartile range. *P < 0.05