Table 2 Comparison of laboratory parameters between patients with IgG4-ROD and nIgG4-ROD

Low serum C3, n (%)

87(39.7)

51(34.7)

0.330

Low serum C4, n (%)

75(34.7)

44(29.9)

0.340

Hypocomplementemia, n (%)

100(45.9)

63(42.9)

0.570

Elevated ESR, n (%)

94(49.5)

78(55.3)

0.293

Elevated CRP, n (%)

30(16.3)

45(31.9)

0.001*

Elevated globulin, n (%)

54(28.6)

41(29.1)

0.920

Eosinophilia, n (%)

60(27.8)

33(21.6)

0.176

RF+, n (%)

43(20.5)

26(18.7)

0.684

ANA+, n (%)

32(14.3)

25(16.7)

0.542

Elevated IgE, n (%)

178(84.0)

77(71.3)

0.008*

C3 (g/L), mean ± SD

0.852 ± 0.280

0.935 ± 0.319

0.053

C4 (g/L), mean ± SD

0.184 ± 0.095

0.200 ± 0.093

0.115

ESR (mm/h), median (IQR)

18.5(8.0–40.0)

23.5(10.0–59.0)

0.058

CRP (mg/L), median (IQR)

2.24(1.00–4.70)

3.05(1.26–12.45)

0.004*

Globulin (g/L), median (IQR)

33.7(29.7–41.5)

35.4(29.8–41.5)

0.808

Serum IgG4 (mg/dl), median (IQR)

983(409–1838)

523(225–1370)

< 0.001*

Serum IgG (g/L), median (IQR)

17.5(14.3–23.2)

17.2(14.1–22.0)

0.609

IgG4/IgG, median (IQR)

0.529(0.272–0.879)

0.294(0.143–0.629)

< 0.001*

Serum IgE (IU/ml), median (IQR)

339.7(160.8–847.6)

259.4(83.1–653.3)

0.022*