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Table 7 Risk of gout in relation to the combination of BMI, alcohol drinking, and ALDH2 rs671 polymorphism

From: Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake

Variables

OR

95% CI

p-value

ALDH2 rs671 genotypes, BMI, and alcohol drinking (ref, GG, normal BMI, no alcohol drinking)

 GG, normal BMI, and alcohol drinking

1.929

1.385–2.688

0.0001

 GG, abnormal BMI, and no alcohol drinking

1.721

1.442–2.052

< 0.0001

 GG, abnormal BMI, and alcohol drinking

1.941

1.501–2.511

< 0.0001

 GA+AA, normal BMI, and no alcohol drinking

0.937

0.779–1.126

0.4862

 GA+AA, normal BMI, and alcohol drinking

1.971

1.167–3.327

0.0111

 GA+AA, abnormal BMI, and no alcohol drinking

1.498

1.256–1.786

< 0.0001

 GA+AA, abnormal BMI, and alcohol drinking

1.545

1.088–2.194

0.0150

Sex (ref, women)

 Men

2.355

2.061–2.692

< 0.0001

Age group (ref, 30–40 years)

 41–50

0.709

0.613–0.820

< 0.0001

 51–60

0.849

0.732–0.984

0.0297

 61–70

0.869

0.731–1.032

0.1083

Waist-hip ratio (ref, normal)

 Abnormal

1.362

1.216–1.527

< 0.0001

Body fat (ref, normal)

 Abnormal

1.450

1.276–1.647

< 0.0001

Cigarette smoking status (ref, never)

 Former

0.937

0.799–1.100

0.4268

 Current

0.782

0.659–0.928

0.0049

Coffee consumption (ref, no)

 Yes

1.058

0.948–1.180

0.3177

Tea consumption (ref, no)

 Yes

1.223

1.099–1.360

0.0002

Exercise (ref, no)

 Yes

1.039

0.930–1.160

0.5007

Diet status (ref, non-vegetarian)

 Former vegetarian

1.006

0.787–1.286

0.9623

 Vegan

0.656

0.497–0.867

0.0030

Blood urea nitrogen (ref, normal)

 Abnormal

1.426

1.123–1.812

0.0036

Creatinine (ref, normal)

 Abnormal

5.324

2.845–9.962

< 0.0001

HDL-C

0.980

0.975–0.985

< 0.0001

LDL-C

1.006

1.005–1.008

< 0.0001

Triglycerides

1.003

1.002–1.004

< 0.0001

  1. BMI body mass index, OR odds ratio, CI confidence interval, ref reference, ALDH2 Aldehyde dehydrogenase 2, HDL-C high-density lipoprotein cholesterol, LDC-C low-density lipoprotein cholesterol