Fig. 2

Still’ disease interactome a considering all disease effectors and their direct interactors and b focusing on disease effectors and their interaction to drug targets, and comparison to c pathway enrichment results of sJIA gene expression data. The network around Still’s disease characterization was constructed using the bibliographic characterization and interaction databases (a) presents enrichment of pathways found also enriched within the independent disease expression data (c). The network created around Still’s disease includes all drug targets evaluated in the study directly interacting with at least one effector of the disease (b). ANA, anakinra; CAN, canakinumab; CS, corticosteroids; MTX, methotrexate; SAR, sarilumab; TCZ, tocilizumab