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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis

Fig. 1

Detection of anti-PAD4 and anti-PAD3/4 IgG at different anatomical sites. Antibodies to PAD4, including those of the PAD3/4 subset, were detected in paired serum (Se), sputum (Sp), and saliva (Sa) samples from RA patients (n = 37), individuals at-risk (AR) for RA (n = 46), and healthy controls (n = 35). a The overlap in anti-PAD4 antibody positivity at the three anatomical sites in anti-PAD4-positive individuals (n = 7) is depicted using a Venn diagram. Anti-PAD3/4 positivity did not overlap between serum, sputum, and saliva. Heat maps show the anti-PAD antibody arbitrary units (AU) b and anti-CCP units c in anti-PAD-positive individuals (n = 7) at the various anatomical sites. Salivary samples that were not available for anti-CCP testing are marked with an X

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Arthritis Research & Therapy

ISSN: 1478-6362

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