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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Circulating mature granzyme B+ T cells distinguish Crohn’s disease-associated axial spondyloarthritis from axial spondyloarthritis and Crohn’s disease

Fig. 2

Cytotoxic GZMB+ T cells are expanded in CD-axSpA. Singlet, viable lymphocytes were gated for CD3+ TCRβ+ followed by CD4+ and CD8+ subsets. a Within the CD4+ and b CD8+ T cell populations, the percent GZMB+ are shown. Next, within the (c) CD4+ GZMB+ and (d) CD8+ GZMB+ T cell subpopulations, the percent expressing the inhibitory co-receptor NKG2a+ are shown. e Within the viable lymphocyte gate, the percent TCRγδ+ and within that population f the percent GZMB+ are shown. All data are individual subject values (symbols) with bars as the mean ± SEM. *, P < 0.05; **, P < 0.01 as determined by t-test for parametric data and Mann-Whitney for non-parametric data as determined by D’Agostino test

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Arthritis Research & Therapy

ISSN: 1478-6362

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