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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner

Fig. 6

1,25(OH)2D3 can reduce SF activation and the pro-inflammatory loop. CCR6+ subpopulations were cultured with SF for 3 days with stimulation from anti-CD3 and anti-CD28 in the presence of 100 nM 1,25(OH)2D3. a, b Representative flow cytometry plots and quantification of 6 healthy donors displaying IL-17A, IL-22, and IFNγ-producing cells after 3 days of culture. c, d Expression levels of cytokines, MMPs, and PGE2 in culture supernatant on day 3. Data show mean ± SEM from n = 6 healthy controls, representative of at least 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Arthritis Research & Therapy

ISSN: 1478-6362

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