Table 3 Unadjusted and adjusted (multivariable) associations between independent variables (clinical and fixed variables) and radiographic OA progression (JSN ≥ 0 .5mm)
Independent variables | Exposed with progression | Non-exposed with progression | Unadjusted odds ratio (95% CI) | Adjusted odds ratio (95% CI) | p-value |
|---|---|---|---|---|---|
Radiographic OA progression (R 2 = 16%) | |||||
Clinical factors | |||||
Use of NSAIDs | 15.0% | 10.3% | 1.53 (0.86, 2.72) | 2.05 (1.10, 3.84) | 0.025 |
Inadequate physical activity | 13.2% | 6.8% | 2.08 (0.96, 4.53) | 2.07 (0.92, 4.68) | 0.080 |
Fixed variables | |||||
Minimal joint space width (<3.13mm) | 23.3% | 8.1% | 3.44 (1.95, 6.05) | 2.53 (1.31, 4.88) | 0.006 |
Varus alignment (≤178°) | 26.0% | 9.3% | 3.45 (1.86, 6.39) | 2.23 (1.09, 4.57) | 0.028 |
Disease severity (K&L grade ≥2) | 17.3% | 7.0% | 2.80 (1.57, 5.01) | 1.88 (0.98, 3.58) | 0.056 |
Age (>60 years) | 12.5% | 10.6% | 1.20 (0.69,2.10) | 1.02 (0.56, 1.87) | 0.939 |
Sex (female) | 10.3% | 13.4% | 0.74 (0.43, 1.28) | 0.88 (0.48, 1.60) | 0.666 |
Obesitya | 11.8% | 11.5% | 1.02 (0.59, 1.77) | 1.17 (0.64, 2.14) | 0.603 |
High blood pressure | 10.4% | 12.2% | 0.84 (0.46, 1.52) | 0.65 (0.34, 1.25) | 0.198 |
High baseline pain (WOMAC pain >10) | 7.1% | 13.0% | 0.52 (0.24, 1.13) | 0.52 (0.23, 1.18) | 0.118 |
No glucosamine/chondroitin combination | 12.5% | 9.3% | 1.39 (0.71, 2.71) | 1.26 (0.62, 2.56) | 0.521 |