Radiographic OA progression (R 2 = 16%)
|
Clinical factors
|
Use of NSAIDs
|
15.0%
|
10.3%
|
1.53 (0.86, 2.72)
|
2.05 (1.10, 3.84)
|
0.025
|
Inadequate physical activity
|
13.2%
|
6.8%
|
2.08 (0.96, 4.53)
|
2.07 (0.92, 4.68)
|
0.080
|
Fixed variables
|
Minimal joint space width (<3.13mm)
|
23.3%
|
8.1%
|
3.44 (1.95, 6.05)
|
2.53 (1.31, 4.88)
|
0.006
|
Varus alignment (≤178°)
|
26.0%
|
9.3%
|
3.45 (1.86, 6.39)
|
2.23 (1.09, 4.57)
|
0.028
|
Disease severity (K&L grade ≥2)
|
17.3%
|
7.0%
|
2.80 (1.57, 5.01)
|
1.88 (0.98, 3.58)
|
0.056
|
Age (>60 years)
|
12.5%
|
10.6%
|
1.20 (0.69,2.10)
|
1.02 (0.56, 1.87)
|
0.939
|
Sex (female)
|
10.3%
|
13.4%
|
0.74 (0.43, 1.28)
|
0.88 (0.48, 1.60)
|
0.666
|
Obesitya
|
11.8%
|
11.5%
|
1.02 (0.59, 1.77)
|
1.17 (0.64, 2.14)
|
0.603
|
High blood pressure
|
10.4%
|
12.2%
|
0.84 (0.46, 1.52)
|
0.65 (0.34, 1.25)
|
0.198
|
High baseline pain (WOMAC pain >10)
|
7.1%
|
13.0%
|
0.52 (0.24, 1.13)
|
0.52 (0.23, 1.18)
|
0.118
|
No glucosamine/chondroitin combination
|
12.5%
|
9.3%
|
1.39 (0.71, 2.71)
|
1.26 (0.62, 2.56)
|
0.521
|