Fig. 4

Disease activity at week 12 according to serum levels of TNF at 24 h after the CZP therapy: TNF-high vs. -low. A Left panel: ROC curve of serum TNFα concentration at 24 h after the first dose of CZP and the cut-off value to predict DAS28(ESR)<2.6 at week 12, right panel: comparison of DAS28(ESR) <2.6 rate at week 12 between the 2 groups based on whether the serum TNFα concentration at 24 h was above or below the cut-off value; p value according to Fisher’s exact test. B Left panel: cumulative probability plot of serum TNFα concentrations at baseline and 24 h in the group achieving DAS28(ESR)<2.6 at week 12; right panel: cumulative probability plot of serum TNFα concentrations at baseline and 24 h in the group not achieving DAS28(ESR)<2.6 at week 12, ● = serum TNFα concentration at baseline, ◇ = serum TNFα concentration at 24 h after CZP initiation