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Table 1 Clinical and immunological characteristics of APS patients, "aPL carriers", and CTR patients

From: Antiphospholipid antibodies and anticoagulant therapy: capillaroscopic findings

 

APS

"aPL carriers"

CTR

Total patients

18

24

18

Female–male sex

13–5

23–1

8–10

Age (years, mean ± SD)

50 ± 13.8

46.4 ± 16.4

74 ± 12.5

Disease duration (years, mean ± SD)

7.6 ± 7.7

Primary–secondary forms

12–6

17–7

Arterial/venous thrombosis

16/18 (88.9)

9 (50.0)

Pregnancy morbidity

3/13 (23.1)

Atrial fibrillation

6 (33.3)

Mechanical heart valves

3 (16.7)

Arterial hypertension

6

8

6

Diabetes mellitus

0

1

2

LAC positivity

5/18 (27.8)

5/24 (20.8)

ACL IgG positivity

4/18 (22.2)

9/24 (37.5)

ACL IgM positivity

9/18 (50.0)

5/24 (20.8)

Anti-b2GPI IgG positivity

5/18 (27.8)

8/24 (33.3)

Anti-b2GPI IgM positivity

8/18 (44.4)

12/24 (50.0)

Single positivitya

10/18 (55.5)

13/24 (54.1)

Double positivityb

5/18 (27.8)

10/24 (41.7)

Triple positivityc

3/18 (16.7)

1/24 (4.2)

  1. APS antiphospholipid syndrome, aPL antiphospholipid antibodies, CTR control, SD standard deviation, LAC lupus anticoagulant, ACL anticardiolipin antibodies, anti-b2GPI antibeta2 glycoprotein I antibodies
  2. aSingle positivity is defined as the positivity of only one between LAC, ACL IgG/M, and anti-b2GPI IgG/M
  3. bDouble positivity is defined as the positivity of two between LAC, ACL IgG/M, and anti-b2GPI IgG/M, variously mixed
  4. cTriple positivity is defined as the positivity of three between LAC, ACL IgG/M, and anti-b2GPI IgG/M, variously mixed