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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis

Fig. 1

M808 is a selective HDAC6 inhibitor. a Selectivity of M808 for HDAC6. Inhibition of HDAC is dependent on the M808 concentration (IC50 values are shown). b Kinetics of M808 were determined by measuring the activity of HDAC6 in the presence of M808. c Cells were incubated with IL-1β and increasing concentrations of M808. Cell viability was then measured. AMC, RHKK-AC-AMC; IC50, the half maximal inhibitory concentration; IL, interleukin; Ki, inhibitory constant; ND, not determined; S, substrate; V, velocity

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Arthritis Research & Therapy

ISSN: 1478-6362

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