Fig. 5

M808 increases body weight and reduces the clinical score of arthritis in an AIA model. a Experimental design. Arthritis was induced in Lewis rats as described in the “Methods” section. Rats received a daily dose of M808 (0, 3, 10, 30, 50, or 100 mg/kg; n = 9, 9, 9, 7, 7, and 8, respectively), starting on the day before CFA injection. b, c Weight (b) and clinical scores over the treatment period are shown. P values were generated using repeated measures ANOVA. d Synovial inflammation, bone erosion, and cartilage damage were graded after histological examination. e Representative histology images. Data represent the mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. the M808 0 mg/kg group. CFA, complete Freud’s adjuvant