Fig. 1

Oxylipin profile is different in PsO patients by skin disease activity. A PLS-DA scores plot of PsO patients with higher (N = 12) versus lower PASI (N = 8). The explained variances for each component are shown in brackets. B Important features identified by PLS-DA. The colored boxes on the right indicate the relative concentrations of the corresponding metabolite in each group under study. C Heatmap performed using the important features identified by PLS-DA which shows different patterns in the 2 groups. D Precursor assignment for the oxylipins that are decreased (blue rectangle) in PsO patients with higher disease activity compared to the lower group