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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants

Fig. 4

Protein-protein interaction network in STRING of proteins encoded by differentially expressed genes. Only connected (N = 116 genes) genes that were identified to be differentially expressed between mechanically stressed and control cartilage of osteochondral explants are shown. Two clusters with high interactions were identified upon studying connections within STRING. One cluster corresponds with genes found in the cellular senescence pathway (dotted circle), while the other cluster consists of proteins that are involved in IGF-1 signaling (black circle)

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Arthritis Research & Therapy

ISSN: 1478-6362

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