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Table 1 Sensitivity of α-citrullinated hnRNP-DLmir (cit-DL), α-hnRNP-DLmir (DL) autoantibodies and Δ OD between cit-DL and DL (ΔDL) in sera from Risk-RA patients, early RA patients (LURA/ EIRA), established RA patients (predict), SLE patients (n = 89), other diseases and healthy controls determined by ELISA. Sensitivities are expressed as percentages, with a 98% specificity, and were calculated using two cutoffs in each case, first, against healthy controls (to the left of the slash) and second, against other diseases except SLE (to the right of the slash). Total DL is the combined antibody reactivity and describes the proportion of patients that one detects positive overall with the combination of all three biomarkers α-cit-DL, α-DL and/or ΔDL

From: The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients

 

cit-DL

DL

ΔDL

total DL

RF and/or CCP positive

RF and CCP negative

cit-DL

DL

ΔDL

total DL

cit-DL

DL

ΔDL

total DL

Risk-RA

n = 71

   

n = 71

   

n = 0

   

% pos.

70/28

13/6

68/34

80/39

70/28

13/6

68/34

80/39

-

-

-

-

LURA

n = 106

   

n = 81

   

n = 25

   

% pos.

64/38

8/4

64/40

69/42

77/48

7/2

77/52

80/53

24/4

12/8

24/0

32/8

EIRA

n = 404

   

n = 202

   

n = 202

   

% pos.

80/33

21/9

68/31

84/40

94/59

17/5

89/59

96/63

65/7

25/14

46/2

73/17

Predict

n = 127

   

n = 86

   

n = 41

   

% pos.

100/67

6/0

100/72

100/72

100/77

6/0

100/83

100/83

100/46

5/0

100/51

100/51

SLE

n = 89

           

% pos.

80/58

34/18

72/57

84/73

        

other

n = 127

           

% pos.

45/2

4/2

41/2

48/4

        

HC

n = 86

           

% pos.

2/0

2/0

2/0

5/0

        
  1. HC healthy controls, RA rheumatoid arthritis, SLE systemic lupus erythematosus