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Table 2 Risk of rheumatoid arthritis in statin users compared to non-users

From: Risk of rheumatoid arthritis diagnosis in statin users in a large nationwide US study

Exposure Cases (n = 16,363) Controls (n = 16,363) OR1 (95% CI) OR2 (95% CI) OR3 (95% CI) OR4 (95% CI)
Statin user status
 Non-user 10854 11199 1.00 1.00 1.00 1.00
 Statin user 5509 5164 1.12 (1.06, 1.18) 1.14 (1.08, 1.20) 1.07 (1.01, 1.13) 0.95 (0.90, 1.01)
 Current user 2629 (47.7) 2680 (51.9) 1.03 (0.97, 1.10) 1.05 (0.98, 1.12) 0.98 (0.92, 1.05) 0.87 (0.81, 0.93)
 Former user 2880 (52.3) 2484 (48.1) 1.21 (1.13, 1.28) 1.23 (1.15, 1.31) 1.15 (1.08, 1.23) 1.03 (0.96, 1.10)
Statin use duration
 <1 year statin use 996 (18.1) 856 (16.6) 1.20 (1.09, 1.33) 1.22 (1.11, 1.34) 1.16 (1.05, 1.27) 1.04 (0.94, 1.15)
 ≥1 year statin use 3917 (71.1) 3795 (73.5) 1.08 (1.02, 1.15) 1.10 (1.04, 1.17) 1.04 (0.98, 1.10) 0.91 (0.86, 0.97)
 Unknown 596 (10.8) 513 (9.9) 1.20 (1.07, 1.36) 1.23 (1.09, 1.39) 1.14 (1.01, 1.29) 1.02 (0.90, 1.16)
Statin use intensity
 Low 519 (9.4) 505 (9.8) 1.08 (0.95, 1.23) 1.10 (0.97, 1.25) 1.04 (0.91, 1.18) 0.93 (0.82, 1.06)
 Medium 3486 (63.3) 3290 (63.7) 1.11 (1.05, 1.18) 1.12 (1.06, 1.19) 1.07 (1.01, 1.13) 0.95 (0.89, 1.01)
 High 1504 (27.3) 1369 (26.5) 1.15 (1.06, 1.25) 1.18 (1.09, 1.28) 1.08 (1.00, 1.18) 0.96 (0.88, 1.05)
  1. 1Model 1: Adjusted for age, sex, race/ethnicity, calendar year of index date, and geographical region
  2. 2Model 2: Model 1 + adjustment for Charlson Comorbidity Index
  3. 3Model 3: Model 1 + adjustment for Elixhauser Comorbidity Index
  4. 4Model 4: Model 3 + adjustment for hyperlipidemia