Table 2 Risk of rheumatoid arthritis in statin users compared to non-users
From: Risk of rheumatoid arthritis diagnosis in statin users in a large nationwide US study
Exposure | Cases (n = 16,363) | Controls (n = 16,363) | OR1 (95% CI) | OR2 (95% CI) | OR3 (95% CI) | OR4 (95% CI) |
|---|---|---|---|---|---|---|
Statin user status | ||||||
 Non-user | 10854 | 11199 | 1.00 | 1.00 | 1.00 | 1.00 |
 Statin user | 5509 | 5164 | 1.12 (1.06, 1.18) | 1.14 (1.08, 1.20) | 1.07 (1.01, 1.13) | 0.95 (0.90, 1.01) |
 Current user | 2629 (47.7) | 2680 (51.9) | 1.03 (0.97, 1.10) | 1.05 (0.98, 1.12) | 0.98 (0.92, 1.05) | 0.87 (0.81, 0.93) |
 Former user | 2880 (52.3) | 2484 (48.1) | 1.21 (1.13, 1.28) | 1.23 (1.15, 1.31) | 1.15 (1.08, 1.23) | 1.03 (0.96, 1.10) |
Statin use duration | ||||||
 <1 year statin use | 996 (18.1) | 856 (16.6) | 1.20 (1.09, 1.33) | 1.22 (1.11, 1.34) | 1.16 (1.05, 1.27) | 1.04 (0.94, 1.15) |
 ≥1 year statin use | 3917 (71.1) | 3795 (73.5) | 1.08 (1.02, 1.15) | 1.10 (1.04, 1.17) | 1.04 (0.98, 1.10) | 0.91 (0.86, 0.97) |
 Unknown | 596 (10.8) | 513 (9.9) | 1.20 (1.07, 1.36) | 1.23 (1.09, 1.39) | 1.14 (1.01, 1.29) | 1.02 (0.90, 1.16) |
Statin use intensity | ||||||
 Low | 519 (9.4) | 505 (9.8) | 1.08 (0.95, 1.23) | 1.10 (0.97, 1.25) | 1.04 (0.91, 1.18) | 0.93 (0.82, 1.06) |
 Medium | 3486 (63.3) | 3290 (63.7) | 1.11 (1.05, 1.18) | 1.12 (1.06, 1.19) | 1.07 (1.01, 1.13) | 0.95 (0.89, 1.01) |
 High | 1504 (27.3) | 1369 (26.5) | 1.15 (1.06, 1.25) | 1.18 (1.09, 1.28) | 1.08 (1.00, 1.18) | 0.96 (0.88, 1.05) |