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Table 3 Reduction of pathological bone shape change (B-score) by TPX-100 treatment tends to improve in the knees with higher ICRS grades at baseline. 6 and 12-month B-score changes of index and control knees were compared among the baseline tibiofemoral ICRS grade cohorts. Data of baseline ICRS grade ≥ 0 (i.e., all knees) are the same as those shown in Fig. 3 and comparison between index and control knees was by paired t-test. Because index and control knees in the higher baseline ICRS grade cohorts did not necessarily belong to the same subjects, the comparisons in these three cohorts are by unpaired t-tests

From: Study TPX-100-5: intra-articular TPX-100 significantly delays pathological bone shape change and stabilizes cartilage in moderate to severe bilateral knee OA

Baseline tibiofemoral ICRS grade Mean baseline B-score (number of knees) B-score difference between index and control knees
6 months 12 months
Index Control Difference p Difference p
≥ 0 (All) 1.48 (78) 1.48 (78) 0.09 0.02 0.11 0.01
≥ 2 1.76 (62) 1.78 (57) 0.08 0.09 0.11 0.07
≥ 3 2.15 (48) 2.39 (41) 0.16 0.01 0.13 0.09
4 2.84 (27) 3.01 (26) 0.23 0.01 0.16 0.14