Table 3 Reduction of pathological bone shape change (B-score) by TPX-100 treatment tends to improve in the knees with higher ICRS grades at baseline. 6 and 12-month B-score changes of index and control knees were compared among the baseline tibiofemoral ICRS grade cohorts. Data of baseline ICRS grade ≥ 0 (i.e., all knees) are the same as those shown in Fig. 3 and comparison between index and control knees was by paired t-test. Because index and control knees in the higher baseline ICRS grade cohorts did not necessarily belong to the same subjects, the comparisons in these three cohorts are by unpaired t-tests

From: Study TPX-100-5: intra-articular TPX-100 significantly delays pathological bone shape change and stabilizes cartilage in moderate to severe bilateral knee OA