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Table 2 Standardized incidence ratios (SIRs) of cancers in patients with RPF

From: Association of retroperitoneal fibrosis with malignancy and its outcomes

 

Observed

Expected

SIR [95% CI]

Corrected p

Overall SIR

38

17.1

2.2 [1.6, 3.1]

<0.001

 Male

26

13.7

1.9 [1.2, 2.8]

<0.001

 Female

12

3.4

3.5 [1.8, 6.2]

<0.001

Age-specific SIR

 30–39

1

0.23

4.3 [0.1, 23.7]

0.419

 40–49

4

0.91

4.4 [1.2, 11.2]

0.028

 50–59

8

2.83

2.8 [1.2, 5.6]

0.017

 60–69

11

6.58

1.7 [0.8, 3.0]

0.143

 70–79

12

5.48

2.2 [1.1, 3.8]

0.022

 ≥ 80

2

1.00

2.0 [0.2, 7.2]

0.529

Interval-specific SIR, yearsa

 −20 ~ −5

5

6.47

0.77 [0.3, 1.8]

0.747

 −5 ~ −3

0

1.95

0

 −3 ~ −1

4

2.26

1.8 [0.5, 4.6]

0.365

 −1 ~ +1

22

2.22

9.9 [6.2, 15.0]

<0.001

 +1 ~ +3

2

1.33

1.5 [0.2, 5.4]

0.771

 +3 ~ +5

3

0.83

3.6 [0.8, 10.6]

0.102

 +5 ~

2

2.02

1.0 [0.1, 3.6]

1.000

Cancer type-specific SIR

 Lung

4

2.7

1.5 [0.4, 3.9]

0.555

 Stomach

6

3.3

1.8 [0.7, 4.0]

0.228

 GIST

1

0.06

16.4 [0.4, 91.2]

0.119

 Colon

3

1.26

2.4 [0.5, 7.0]

0.268

 Rectum

1

1.05

1.0 [0.0, 5.3]

1.000

 Pancreas

2

0.49

4.1 [1.0, 14.8]

0.174

 Kidney

2

0.31

6.4 [0.8, 23.2]

0.079

 Renal pelvis

3

0.04

74.4 [15.4, 217.5]

<0.001

 GB and biliary tract

1

0.53

1.9 [0.1, 10.6]

0.818

 Bladder

1

0.46

2.2 [0.1, 12.1]

0.739

 Prostate

1

1.04

1.0 [0.0, 5.4]

1.000

 MM

2

0.11

19.0 [2.3, 68.5]

0.010

 NHL

1

0.29

3.5 [0.1, 19.4]

0.500

 Connective and soft tissue

1

0.06

15.5 [0.4, 86.2]

0.125

 MDS

1

0.06

16.8 [0.4, 93.5]

0.116

 Thyroid

2

0.74

2.7 [0.3, 9.8]

0.339

 Breast

1

0.41

2.4 [0.1, 13.4]

0.679

 Cervix uteri

1

0.18

5.5 [0.1, 30.9]

0.330

 Larynx

1

0.19

5.3 [0.1, 29.7]

0.342

 Skinb

1

0.25

3.9 [0.1, 21.9]

0.449

 Unknown primary

2

0.20

9.8 [1.2, 35.4]

0.037

  1. Data are expressed as SIR (95% CI). RPF retroperitoneal fibrosis; GIST gastrointestinal stromal tumor; GB gall bladder; MM multiple myeloma; NHL non-Hodgkin lymphoma; MDS myelodysplastic syndrome. aThe interval was calculated using the data of RPF diagnosis as a reference. bGiven that the Korean National Cancer Registry data were available between 1999 and 2016, the 1999 cancer incidence was used to extrapolate the expected cancer occurrence for a skin cancer that was diagnosed in 1996