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Table 3 ROC curve in each subset determined by univariate/multivariable logistic regression analysis

From: Granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-α in combination is a useful diagnostic biomarker to distinguish familial Mediterranean fever from sepsis

Variables (FMF vs. sepsis) Sensitivity Specificity Accuracy AUC AIC Cutoff value (pg/mL or predicted probability*)
GM-CSF 0.86 0.94 0.89 0.95 30.3 8.3
TNF-α 0.82 0.78 0.80 0.82 62.7 16.3
VEGF 0.90 0.75 0.82 0.83 54.3 67.1
GM-CSF + TNF-α 0.93 0.94 0.93 0.98 19.3 0.75*
GM-CSF + VEGF 0.86 0.94 0.89 0.94 32.3 0.61*
TNF-α + VEGF 0.93 0.83 0.89 0.91 42.4 0.55*
  1. Bold indicates the minimum number of cytokines among the subsets. AIC Akaike’s information criterion; AUC area under the curve; GM-CSF granulocyte-macrophage colony-stimulating factor; TNF-α tumor necrosis factor-alpha; VEGF vascular endothelial growth factor