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Table 1 Influence of baseline BMI on RA disease activity, pain and fatigue over 12 months

From: Baseline predictors of remission, pain and fatigue in rheumatoid arthritis: the TITRATE trial

   Crude Adjusteda
β (95%CI) p value β (95%CI) p value
Average scores (0, 6 and 12 months)
DAS28-ESR Normal Reference   Reference  
Overweight 0.15 (-0.07,0.38) 0.181 0.08 (-0.15,0.31) 0.506
Obese 0.38 (0.14,0.61) 0.002 0.29 (0.05,0.53) 0.017
Pain Normal Reference   Reference  
Overweight 6.00 (0.86,11.13) 0.022 5.17 (0.29,10.05) 0.038
Obese 8.48 (3.36,13.60) 0.001 8.16 (3.12,13.21) 0.002
Fatigue Normal Reference   Reference  
Overweight 3.59 (-2.61,9.79) 0.256 3.36 (-2.05,8.77) 0.224
Obese 7.96 (1.86,14.05) 0.010 5.66 (0.02,11.30) 0.049
12-month outcomes
   Crude
Odds ratio (95%CI)
p value Adjusteda
Odds ratio (95%CI)
p value
Remission DAS28-ESR (<2.6) Normal Reference   Reference  
Overweight 0.95 (0.52, 1.70) 0.853 0.97 (0.50, 1.87) 0.925
Obese 0.32 (0.15, 0.67) 0.002 0.33 (0.16, 0.72) 0.005
Change in Pain (≥10 units) Normal Reference   Reference  
Overweight 1.00 (0.58, 1.72) 0.996 1.11 (0.62, 2.00) 0.719
Obese 0.74 (0.42, 1.29) 0.287 0.68 (0.37, 1.24) 0.213
Change in Fatigue (≥10 units) Normal Reference   Reference  
Overweight 0.69 (0.40, 1.18) 0.172 0.76 (0.42, 1.37) 0.362
Obese 0.53 (0.30, 0.94) 0.029 0.53 (0.29, 0.98) 0.043
  1. aAdjustment for age, gender, ethnicity, disease duration, NHS region and trial arm; BMI: normal n=102, overweight n=105, obese n=92