Fig. 6

Cytokine and cell expression in DM lesional skin treated with Lenabasum versus placebo. Skin biopsies from lesional DM skin stained via immunohistochemistry for a CD4+ cells, b IFN-β, c IFN-γ, d IL-31, e CB2R, f CD11c+ cells, g CD123+ cells, and h CD8+ cells at week 0 and week 12 following treatment with either lenabasum or placebo. Representative IHC images are pictured at ×20 objective magnification. Quantification of cell counts and percentage of area stained positive are pictured adjacently. Cells were counted in five non-overlapping ×40 fields and averaged. Percentage of area stained positive was quantified in one ×20 field. Epidermis excluded. Graph shows the median. *p<0.05