Table 2 Decline in biomarker levels over time in ACPA-negative RA patients achieving SDFR compared to those who did not
No SDFR, β (95%CI) | SDFR, β (95%CI) | p-value | Decline in SDFR vs. non-SDFR, ratio (95%CI) | |
|---|---|---|---|---|
MMP-3 (log-pg/ml) | ||||
Baseline | 10.74 (10.54, 10.94) | 10.80 (10.31, 11.29) | 0.660 | |
Change 0–12 months | − 0.35 (− 0.60, − 0.09) | − 0.71 (− 0.96, − 0.45) | 0.048 | 1.44× (1.00–2.06) |
Change 12–24 months | − 0.28 (− 0.55, + 0.00) | − 0.07 (− 0.35, + 0.22) | 0.305 | 0.81× (0.55–1.21) |
MMP-1 (log-pg/ml) | ||||
Baseline | 9.12 (8.95, 9.28) | 9.28 (8.88, 9.68) | 0.174 | |
Change 0–12 months | − 0.04 (− 0.17, + 0.09) | − 0.30 (− 0.44, − 0.17) | 0.006 | 1.30× (1.08–1.57) |
Change 12–24 months | − 0.06 (− 0.20, + 0.09) | − 0.04 (− 0.19, + 0.11) | 0.836 | 0.98× (0.80–1.20) |
SAA (log-μg/ml) | ||||
Baseline | 1.95 (1.62, 2.29) | 2.51 (1.70, 3.17) | 0.023 | |
Change 0–12 months | − 1.28 (− 1.75, − 0.81) | − 2.03 (− 2.50, − 1.55) | 0.028 | 2.12× (1.08–4.14) |
Change 12–24 months | − 0.00 (− 0.53, + 0.52) | + 0.07 (− 0.47, + 0.60) | 0.851 | 0.93× (0.44–0.93) |
CRP (log-μg/ml) | ||||
Baseline | 2.68 (2.34, 3.03) | 3.00 (2.15, 3.84) | 0.216 | |
Change 0–12 months | − 1.46 (− 1.93, − 1.00) | − 2.27 (− 2.74, − 1.80) | 0.017 | 2.24× (1.16–4.35) |
Change 12–24 months | − 0.04 (− 0.56, + 0.47) | + 0.32 (− 0.24, + 0.82) | 0.379 | 0.72× (0.34–1.50) |