Fig. 3

High humidity aggravates the severity of collagen-induced arthritis (CIA). a Arthritis scores were assessed every five days starting after day 32. b Left ankle swelling was assessed every five days starting after day 32. c Serum anti-CII IgG was measured by ELISA on days 42 and 56. d Serum anti-CCP was measured by ELISA on days 42 and 56. e Representative images of ankle joint. f Representative images of H&E stained histological of ankle joint. Values are the mean ± SEM. “*” = P<0.05; “**” = P<0.01, “ns” = P ≥ 0.05. CT, control group; MT, inducing collagen-induced arthritis group under 50% humidity; HT, inducing collagen-induced arthritis group under 80% humidity