Skip to main content

Table 1 Significantly altered serum metabolites related to humidity in DBA/1 mice

From: High humidity aggravates the severity of arthritis in collagen-induced arthritis mice by upregulating xylitol and L-pyroglutamic acid

  Day 21 - HT vs. CT Day 42 - HT vs. MT Day 56 - HT vs. MT
VIP P value Trend VIP P value Trend VIP P value Trend
Xylitol 1.40 0.004 ↑ 1.87 0.043 ↑ 1.21 0.000 ↑
L-aspartic acid 1.04 >0.05 — <1.0 >0.05 — 1.36 0.000 ↑
Dodecanoic acid 1.09 0.007 ↑ 1.10 0.019 ↓ <1.0 0.007 —
Pyroglutamic acid 1.10 0.014 ↑ 1.70 0.038 ↑ 1.11 0.002 ↑
Sucrose 2.86 0.034 ↓ <1.0 >0.05 — <1.0 >0.05 —
L-tryptophan 2.07 >0.05 — <1.0 >0.05 — <1.0 0.008 —
Ethanolamine 1.33 >0.05 — <1.0 >0.05 — <1.0 >0.05 —
Triethylene glycol 1.11 >0.05 — <1.0 >0.05 — <1.0 >0.05 —
L-threonine 1.37 >0.05 — 2.27 0.015 ↑ <1.0 >0.05 —
Galactonic acid 1.31 >0.05 — <1.0 >0.05 — <1.0 >0.05 —
L-valine <1.0 >0.05 — 1.52 >0.05 — 1.20 0.001 ↓
Methyl galactoside <1.0 0.011 — 1.39 >0.05 — 1.36 0.000 ↑
L-isoleucine <1.0 >0.05 — 1.20 >0.05 — <1.0 >0.05 —
Glucose oxime <1.0 0.013 — 1.49 >0.05 — 1.17 0.001 ↑
L-alanine <1.0 >0.05 — 1.07 >0.05 — 1.01 0.023 ↓
Malic acid <1.0 >0.05 — 1.24 0.017 ↓ <1.0 >0.05 —
D-gluconic acid <1.0 0.023 — 1.31 0.007 ↓ 1.16 0.000 ↑
D-mannose <1.0 >0.05 — 1.15 >0.05 — 1.27 0.000 ↑
Methyltrifluoroacetamide <1.0 0.039 — <1.0 >0.05 — 1.28 0.000 ↑
Octadecanoic acid <1.0 >0.05 — <1.0 >0.05 — 1.31 0.000 ↑
Campesterol <1.0 0.033 — <1.0 >0.05 — 1.25 0.000 ↑
1-monopalmitin <1.0 0.022 — <1.0 >0.05 — 1.26 0.000 ↑
Glycerol monostearate <1.0 >0.05 — <1.0 >0.05 — 1.23 0.000 ↑
Pyridine <1.0 0.034 — <1.0 >0.05 — 1.25 0.000 ↓
  1. Note: “↑” represents the significant increase caused by humidity; “↓” represents the significant caused by humidity, and “—” represents no significant alteration caused by humidity. CT, control group; MT, inducing collagen-induced arthritis group under 50% humidity; HT, inducing collagen-induced arthritis group under 80% humidity
Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us