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Table 1 Significantly altered serum metabolites related to humidity in DBA/1 mice

From: High humidity aggravates the severity of arthritis in collagen-induced arthritis mice by upregulating xylitol and L-pyroglutamic acid

  Day 21 - HT vs. CT Day 42 - HT vs. MT Day 56 - HT vs. MT
VIP P value Trend VIP P value Trend VIP P value Trend
Xylitol 1.40 0.004 1.87 0.043 1.21 0.000
L-aspartic acid 1.04 >0.05 <1.0 >0.05 1.36 0.000
Dodecanoic acid 1.09 0.007 1.10 0.019 <1.0 0.007
Pyroglutamic acid 1.10 0.014 1.70 0.038 1.11 0.002
Sucrose 2.86 0.034 <1.0 >0.05 <1.0 >0.05
L-tryptophan 2.07 >0.05 <1.0 >0.05 <1.0 0.008
Ethanolamine 1.33 >0.05 <1.0 >0.05 <1.0 >0.05
Triethylene glycol 1.11 >0.05 <1.0 >0.05 <1.0 >0.05
L-threonine 1.37 >0.05 2.27 0.015 <1.0 >0.05
Galactonic acid 1.31 >0.05 <1.0 >0.05 <1.0 >0.05
L-valine <1.0 >0.05 1.52 >0.05 1.20 0.001
Methyl galactoside <1.0 0.011 1.39 >0.05 1.36 0.000
L-isoleucine <1.0 >0.05 1.20 >0.05 <1.0 >0.05
Glucose oxime <1.0 0.013 1.49 >0.05 1.17 0.001
L-alanine <1.0 >0.05 1.07 >0.05 1.01 0.023
Malic acid <1.0 >0.05 1.24 0.017 <1.0 >0.05
D-gluconic acid <1.0 0.023 1.31 0.007 1.16 0.000
D-mannose <1.0 >0.05 1.15 >0.05 1.27 0.000
Methyltrifluoroacetamide <1.0 0.039 <1.0 >0.05 1.28 0.000
Octadecanoic acid <1.0 >0.05 <1.0 >0.05 1.31 0.000
Campesterol <1.0 0.033 <1.0 >0.05 1.25 0.000
1-monopalmitin <1.0 0.022 <1.0 >0.05 1.26 0.000
Glycerol monostearate <1.0 >0.05 <1.0 >0.05 1.23 0.000
Pyridine <1.0 0.034 <1.0 >0.05 1.25 0.000
  1. Note: “↑” represents the significant increase caused by humidity; “↓” represents the significant caused by humidity, and “—” represents no significant alteration caused by humidity. CT, control group; MT, inducing collagen-induced arthritis group under 50% humidity; HT, inducing collagen-induced arthritis group under 80% humidity