Table 1 Comparison of clinical features and laboratory test results between the three distinct clusters of AOSD patients

Number (n, %)

492

170 (34.6)

105 (21.3)

217 (44.1)

Age at onset^a

37.05±14.34

38.99±14.95

36.03±13.25

36.01±14.27

0.0911

Sex (male/female)

108/384

34/136

0/105

74/143

<0.0001

 Fever ≥ 39 °C

485 (98.6)

167 (98.2)

102 (97.1)

216 (99.5)

0.2108

 Rash

417 (84.8)

144 (84.7)

105 (100)

168 (77.4)

<0.0001

 Arthralgia

378 (76.8)

124 (72.9)

105 (100)

149 (68.7)

<0.0001

 Pharyngalgia

310 (63)

92 (54.1)

70 (66.7)

148 (68.2)

0.0118

 Myalgia

124 (25.2)

43 (25.3)

0 (0)

81 (37.3)

<0.0001

 Lymphadenopathy

251 (51)

116 (68.2)

41 (39)

94 (43.3)

<0.0001

 Interstitial lung disease

76 (15.4)

76 (44.7)

0 (0)

0 (0)

<0.0001

 Pleurisy

60 (12.2)

60 (35.3)

0 (0)

0 (0)

<0.0001

 Pericarditis

29 (5.9)

29 (17.1)

0 (0)

0 (0)

<0.0001

 Hepatomegaly

33 (6.7)

33 (19.4)

0 (0)

0 (0)

<0.0001

 Splenomegaly

140 (28.5)

75 (44.1)

0 (0)

65 (30)

<0.0001

 Ferritin > 1500 ng/mL (n, %)

348 (70.7)

132 (77.6)

64 (61)

152 (70)

0.0121

 WBC (10⁹/L)^a

17.9±8.2

18.1±9.5

17.4±7.59

17.9±7.2

0.7541

 PLT (10⁹/L)^a

276±107.7

251.6±106.7

295.6±117.7

286±100.1

0.0008

 Hb (g/L)^a

112.7±20.8

111.1±25.1

110.2±16.1

115.2±18.8

0.0568

 CRP (mg/L)^a

87.7±61.6

92.0±64.4

77.0±55.9

89.5±59.1

0.1224

 ESR (mm/h)^a

72.4±34.5

70.4±37.1

74.3±36.8

73.1±31.1

0.6116

 ALT (U/L)^a

318±652.9

483.8±967.9

116.7±160.9

287±425.7

<0.0001

Infection (n, %)

55 (11.2)

38 (22.4)

1 (1.0)

16 (7.4)

<0.0001

MAS (n, %)

33 (6.7)

33 (19.4)

0 (0)

0 (0)

<0.0001