Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitis

Table 1 The gene identified in CIT analysis for which transcriptomics likely mediates ankylosing spondylitis (AS) risk of DNA methylation

Gene	DMPs			DEGs		Correlation		CIT
Gene	CpGs	△β	FDR	FC	FDR	r	p	p1	p2	p3	p4
FYN	cg02789394	0.056	0.012	0.80	0.019	−0.51	0.002	0.026	0.019	0.040	0.147
	cg06009645	0.054	0.007			−0.45	0.006	0.022	0.025	0.040	0.132
	cg11883561	0.053	0.019			−0.53	0.001	0.049	0.015	0.040	0.288
	cg12389112	0.060	0.013			−0.50	0.002	0.043	0.019	0.040	0.227
	cg25529557	0.061	0.007			−0.47	0.004	0.026	0.025	0.040	0.141
LCK	cg02184418	0.058	0.002	0.76	0.012	−0.480	0.004	0.011	0.019	0.036	0.097
TBC1D10C	cg17161520	0.059	0.016	0.66	0.003	−0.530	0.001	0.038	0.015	0.019	0.339
TCF7	cg20682563	0.053	0.005	0.71	0.008	−0.460	0.005	0.014	0.022	0.047	0.097
CCDC88C	cg07112604	0.053	0.001	0.78	0.007	−0.514	0.002	0.005	0.019	0.030	0.062
	cg13873287	0.060	0.007			−0.463	0.005	0.023	0.019	0.030	0.147
EVL	cg20407362	0.057	0.012	0.68	0.000	−0.567	0.000	0.030	0.011	0.010	0.398
NUP210	cg06143615	0.053	0.003	0.84	0.009	−0.528	0.001	0.011	0.015	0.036	0.097
HTRA1	cg06474225	−0.060	0.030	2.12	0.001	−0.570	0.000	0.032	0.010	0.025	0.334
PMEPA1	cg07538640	0.059	0.010	0.69	0.012	−0.490	0.003	0.026	0.019	0.030	0.176
PRKCH	cg22061465	0.062	0.003	0.68	0.010	−0.506	0.002	0.013	0.019	0.026	0.130
PTCH1	cg20445630	0.057	0.006	0.75	0.022	−0.514	0.002	0.032	0.016	0.020	0.271
RFPL2	cg01124132	0.096	0.018	0.73	0.013	−0.553	0.001	0.032	0.011	0.015	0.345

DMP differentially methylated positions, DEG differentially expressed gene, CIT causal inference test, Δβ difference of methylation between patients with AS and healthy controls, FDR false discovery rate, FC fold change, r Pearson correlation coefficient, p1-4 the significance of the test in step 1-4 in CIT analysis, respectively

ISSN: 1478-6362