Fig. 4
From: Analysis of the fecal and oral microbiota in chronic recurrent multifocal osteomyelitis
Principal coordinate analyses of fecal and oral bacterial community spectra, focusing on the first two dimensions based on the shared presence (Jaccard, A, B) and shared abundance of bacteria among individuals (Bray-Curtis, C, D) highlighting compositional differences with respect to disease in fecal samples (Jaccard: F1,40=1.0621, P=0.0066, R2=0.0259, adj. R2=0.0015; Bray-Curtis: F1,40=1.2848, P=0.0462, R2=0.0311, adj. R2=0.0069) and oral samples (Jaccard: F1,45=1.1673, P=0.0045, R2=0.0253, adj. R2=0.0036; Bray-Curtis: F1,45=1.4153, P=0.0446, R2=0.0305, adj. R2=0.0089). The age vector highlights the direction of significant community changes with respect to subject age in oral samples (Jaccard: F1,43=1.1760, P=0.0033, R2=0.0266, adj. R2=0.0040; Bray-Curtis: F1,43=1.4168, P=0.0445, R2=0.0319, adj. R2=0.0094), while no significant correlations are detectable among fecal samples (Jaccard: F1,39=0.9721, P=0.9626, R2=0.0243, adj. R2=-0.0007; Bray-Curtis: F1,39=1.0220, P=0.3711, R2=0.0255, adj. R2=0.0005). E–H PCoAs visualize the direction and relative strength of significant correlations of physiological parameters in CRMO patients, with presence/absence (E, F) and abundance (G, H) based measures of fecal (E, G) and oral (F, H) microbial communities (see Table S9). Vectors were fitted via the envfit routine for visualization