Fig. 5

Penfluridol is therapeutic against IBD mouse models. DSS-induced colitis and TNBS-induced colitis model were established to assess the treatment effect of penfluridol in NF-κB-activated colitis in which drugs were given once a day by oral gavage. A Disease activity index of DSS-induced colitis model. B Colon length of DSS-induced colitis model. C Representative colon length in each group of DSS-induced colitis model. D H&E staining of colon tissues and quantitative analysis of H&E staining of DSS-induced colitis model. E Body weight of TNBS-induced colitis model. F H&E staining of colon tissues and quantitative analysis of H&E staining of TNBS-induced colitis model. Six mice in each group. One-way analysis of variance and Bonferroni post hoc test were used to test statistical significance of the differences among groups, and repeated measures analysis of variance was used to test statistical differences of clinical scores among different groups (NS = not significance, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). PF: penfluridol