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Table 5 The association between inflammatory marker hCRP and lipid profiles and cardiovascular risk parameters and clinic characteristics of patients with psoriasis

From: The difference of lipid profiles between psoriasis with arthritis and psoriasis without arthritis and sex-specific downregulation of methotrexate on the apolipoprotein B/apolipoprotein A-1 ratio

 

Predictors

Univariate analysis

Stepwise regression analysis

p-value

B

95% CI for B

p-value

B

95% CI for B

hCRP

PASI score at baseline

.000

0.142

(0.084–0.200)

.000

0.144

(0.083–0.205)

 

BMI

.001

0.203

(0.079–0.328)

.003

0.195

(0.065–0.324)

 

ApoB/ApoA1

.000

4.009

(1.777–6.241)

.011

3.153

(0.746–5.56)

 

Smoking

.022

0.821

(0.119–1.522)

.015

0.841

(0.165–1.518)

ApoA1

Sex

.000

−0.128

(−0.129 to −0.086)

.001

−0.091

(−0.142 to −0.039)

 

Age

.000

0.003

(0.002–0.004)

.006

0.002

(0.001–0.004)

 

Weight

.000

−0.005

(−0.006 to −0.003)

.004

−0.003

(−0.005 to −0.001)

 

hCRP

.003

−0.012

(−0.02 to −0.004)

.006

−0.011

(−0.018 to −0.003)

HDL

Sex

.000

−0.228

(−0.297 to −0.159)

.000

−0.008

(−0.011 to −0.005)

 

Weight

.000

−0.010

(−0.013 to −0.008)

.014

−0.096

(−0.173 to −0.019)

ApoB

Diastolic blood pressure

.003

0.003

(0.001–0.005)

.044

0.002

(0.000–0.004)

 

Arthritis

.001

0.063

(0.025–0.101)

.001

0.084

(0.036–0.131)

 

Diabetes

.001

0.081

(0.032–0.130)

.006

0.090

(0.026–0.154)

TC

Sex

.024

−0.252

(−0.471 to −0.033)

.031

−0.253

(0.483 to −0.023)

 

Age

.000

0.017

(0.011–0.024)

.000

0.016

(0.009–0.024)

 

Diastolic blood pressure

.013

0.013

(0.003–0.023)

.015

0.012

(0.002–0.021)

 

Arthritis

.001

0.339

(0.133–0.545)

.002

0.225

(0.002–0.448)

LDL

Diastolic blood pressure

.001

0.015

(0.006–0.024)

.003

0.014

(0.005–0.023)

 

Age at disease onset

.010

0.008

(0.002–0.013)

.014

0.008

(0.002–0.015)

TG

Diabetes

.000

0.657

(0.344–0.970)

.000

0.604

(0.025–0.095)

 

BMI

.000

0.068

(0.033–0.103)

.001

0.060

(0.025–0.095)

ApoB/ApoA1

Arthritis

.021

0.052

(0.008–0.096)

.019

0.066

(0.011–0.120)

 

hCRP

.000

0.015

(0.007–0.023)

.036

0.009

(0.001–0.018)

 

Diastolic blood pressure

.000

0.004

(0.002–0.006)

.014

0.003

(0.001–0.005)

 

Weight

.000

0.005

(0.004–0.007)

.001

0.004

(0.001–0.006)

TC/HDL-C

Sex

.000

0.504

(0.253–0.754)

.006

0.016

(0.005–0.027)

 

Diabetes

.001

0.516

(0.207–0.825)

.008

0.460

(0.121–0.799)

 

Diastolic blood pressure

.000

0.024

(0.013–0.036)

.006

0.016

(0.005–0.027)

 

BMI

.000

0.109

(0.077–0.142)

.000

0.087

(0.050–0.125)

LDL/HDL-C

Diastolic blood pressure

.000

0.021

(0.012–0.030)

.001

0.019

(0.008–0.030)

 

Weight

.000

0.025

(0.018–0.032)

.000

0.020

(0.010–0.030)

LDL/ApoB

Hypertension

.016

−0.172

(−0.310 to −0.033)

.021

-0.168

(−0.310 to −0.026)

  1. Abbreviation: ApoA1 apolipoprotein A1, ApoB apolipoprotein B, HC healthy controls, HDL-C high-density lipoprotein-cholesterol, LDL low-density lipoprotein, Lp(a) lipoprotein A, TC total cholesterol, TG triglyceride
  2. Stepwise multiple regression analysis was performed after adjustment for sex, age, age at disease onset, disease duration, BMI, PASI and BSA scores at baseline, smoking, alcohol, diabetes, and hypertension. Only the significant variables are shown. p < .05 is considered to be statistically significant
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Arthritis Research & Therapy

ISSN: 1478-6362

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