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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome

Fig. 5

Multivariate data analysis shows a strong correlation between anti-Jo1 autoantibody reactivity profile, ILD and arthritis, and poor pulmonary function. A Principal component analysis (PCA) score plot of the baseline data obtained from the patients (cohort 1, n = 44) which demographics are listed in Table 1. B Shared and Unique Structures (SUS) plot obtained from two OPLS-DA models: (1) distinguishing the patients according to anti-Jo1 status (predictive component: R2 = 0.73, Q2 = 0.59) and (2) distinguishing the patients according to ILD status (predictive component: R2 = 0.74, Q2 = 0.60). The data processed is the same as in the PCA plot in cohort 1 (A). The factors that correlated most strongly with anti-Jo1+/ILD+ as well as anti-Jo1−/ILD− are highlighted. C PCA score plot of the baseline data obtained from the patients (cohort 2, n=10) which demographics are listed in Supplementary Table 1. D Shared and Unique Structures (SUS) plot obtained from two OPLS-DA models: (1) distinguishing the patients according to Jo1 status (predictive component: R2=0.86, Q2=0.61) and (2) distinguishing the patients according to ILD status (predictive component: R2=0.76, Q2=0.43). The data processed is the same as in the PCA plot of cohort 2 in C

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Arthritis Research & Therapy

ISSN: 1478-6362

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