Skip to main content
Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis

Fig. 4

Targeted therapies for senescent cells in joint tissues. Senolytics (Quercetin, Dasatinib, USP7 inhibitors, ABT263) by inducing the apoptosis of senescent cells and Senomorphics (Nutlin-3a, Canakinumab, CL82198) by blocking the paracrine secretion of senescent secretory phenotype (SASP) to delay the effect of senescent cells on the development of OA. Senolytics induce apoptosis in senescent cells by restoring the activity of p53. Senomorphics inhibit the secretion of SASP to attenuate the pro-senescence effect of senescent cells on surrounding cells

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us