Table 4 The advantages and disadvantages of experimental animal models for OA and aging
Exp. animal models | Advantages | Disadvantages |
|---|---|---|
Spontaneous model | Mostly similar to the characteristics of human aging, omitting surgery, or drug delivery steps | Long feeding period, poor health, high mortality, and large individual differences |
Drug-induced model | Little trauma, no traumatic synovitis interference, simple operation | Cannot accurately simulate the chronic changes of human osteoarthritis |
Surgical induction model | Short period of establishing model time, high success rate, and high repeatability | Complicated operation, large trauma; hemorrhage and traumatic synovitis easily affect the biochemical metabolism of cartilage and synovium in the early stage of OA |
Transgenic model | Accurate modification to facilitate the study of mechanism | The model establishing process is long and costly. |