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Table 3 Univariate Cox regression analysis for IgG4ROD relapse

From: Pathological count of IgG4-positive plasmacytes suggests extraophthalmic involvement and relapse in patients with IgG4-related ophthalmic disease: a retrospective study

Clinicopathological factor

Number (%)

HR (95% CI)

p value

Age of disease onset (years)

41 (100)

1.017 (0.985–1.050)

0.289

Sex

 Male

20 (48.8)

1

Ref

 Female

21 (51.2)

0.767 (0.344–1.709)

0.516

Bilateral

 Yes

23 (56.1)

1

Ref

 No

18 (43.9)

0.567 (0.247–1.301)

0.199

Lacrimal gland involvement

 Yes

32 (78.0)

1

Ref

 No

9 (22.0)

0.956 (0.584–1.567)

0.859

Systemic involvement (head and neck)

 Yes

15 (36.6)

1

Ref

 No

26 (63.4)

0.711 (0.476–1.064)

0.097#

GC (/LPF)

  < 6

19 (46.3)

1

Ref

  ≥ 6

22 (53.7)

4.073 (1.603–10.350)

0.003#

Pathological IgG4+ plasmacyte (/HPF)

  < 100

14 (34.1)

1

Ref

 100–150

11 (26.9)

4.697 (1.242–17.758)

0.023#

  > 150

16 (39.0)

8.701 (2.394–31.620)

0.001#

Serum IgG4 level (mg/dL)

  < 500

16 (39.0)

1

Ref

  ≥ 500

13 (31.7)

4.055 (1.541–10.676)

0.005#

  1. HR hazard ratio, CI confidence interval, Ref reference, GC germinal center, #p < 0.1