| |
Arthritis score
|
Radiographic score
|
TNF-α (pg/ml)
|
IL-1β (pg/ml)
|
IL-6 (pg/ml)
|
IL-17A (pg/ml)
|
OPG (pg/ml)
|
|---|
|
“Endothelial activation” series
|
|
Control
|
n.d.
|
n.d.
|
4.6 ± 0.9
|
26.1 ± 4.9
|
15.7 ± 1.8
|
2.7 ± 0.6
|
n.d.
|
|
AIA
|
4.0 ± 0.3
|
22.2 ± 1.9
|
15.3 ± 1.5###
|
64.5 ± 5.9###
|
65.0 ± 9.0##
|
25.8 ± 2.8###
|
n.d.
|
|
AIA-cryo
|
2.4 ± 0.3***
|
14.8 ± 1.5**
|
12.8 ± 1.2
|
59.7 ± 5.5
|
44.8 ± 3.1*
|
15.5 ± 2.1**
|
n.d.
|
|
“Leucocyte infiltration” series
|
|
Control
|
n.d.
|
n.d.
|
n.d.
|
n.d.
|
n.d.
|
n.d.
|
n.d.
|
|
AIA
|
5.0 ± 0.2
|
21.0 ± 2.5
|
n.d.
|
n.d.
|
n.d.
|
n.d.
|
n.d.
|
|
AIA-cryo
|
3.0 ± 0.3**
|
14.7 ± 1.0*
|
n.d.
|
n.d.
|
n.d.
|
n.d.
|
n.d.
|
|
“Endothelial function” series
|
|
Control
|
n.d.
|
n.d.
|
5.3 ± 4.5
|
17.2 ± 4.1
|
5.8 ± 2.4
|
5.5 ± 1.3
|
208.5 ± 26.7
|
|
AIA
|
4.6 ± 0.2
|
25.2 ± 1.9
|
5.1 ± 1.4
|
25.3 ± 3.7
|
28.3 ± 3.7###
|
23.6 ± 2.1###
|
220.8 ± 21.0
|
|
AIA-cryo
|
3.1 ± 0.2**
|
18.3 ± 1.7*
|
9.8 ± 5.1
|
31.3 ± 11.9
|
19.3 ± 3.4
|
18.1 ± 1.3*
|
170.3 ± 10.7*
|
- Values are expressed as means ± SEM (n=7–12 rats per group). The treatment was applied from day 10 (onset of arthritis) to day 24 (acute inflammatory phase) for “endothelial activation” and “leucocyte infiltration” series, and until day 33 for “endothelial function” series. Cytokines and OPG were measured in plasma. n.d.: not determined
- ## p<0.01, ### p<0.001 vs control, * p<0.05, **p<0.01, *** p<0.001 vs AIA
