HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status

Table 2 Association statistics between genetic polymorphisms located within the HLA-DRB1 gene and disease mortality

Amino acid/haplotype/group	Inflammatory polyarthritis (IP)						Rheumatoid arthritis (RA)
	All-cause mortality			Cardiovascular mortality			All-cause mortality			Cardiovascular mortality
	Hazard ratio (95% CI)	p value	n	Hazard ratio (95% CI)	p value	n	Hazard ratio (95% CI)	p value	n	Hazard ratio (95% CI)	p value	n
Valine 11	1.16 (1.03, 1.30)	0.015	643 (2514)	1.10 (0.93, 1.30)	0.255	343 (2514)	1.10 (0.95, 1.28)	0.217	367 (1160)	0.96 (0.77, 1.19)	0.699	189 (1160)
Serine 11	0.83 (0.75, 0.94)	0.003	643 (2514)	0.82 (0.70, 0.96)	0.016	343 (2514)	0.83 (0.71, 0.97)	0.022	367 (1160)	0.86 (0.69, 1.07)	0.177	189 (1160)
Difference	1.26 (1.09, 1.45)	0.001		1.23 (1.01, 1.49)	0.038		1.22 (1.01, 1.47)	0.035		1.08 (0.83, 1.41)	0.559
VKA haplotype	1.15 (0.99, 1.34)	0.073	579 (2328)	1.16 (0.94, 1.43)	0.158	310 (2328)	1.14 (0.94, 1.38)	0.190	333 (1078)	1.05 (0.79, 1.40)	0.715	167 (1078)
SEA haplotype	0.76 (0.59, 0.96)	0.024	579 (2328)	0.67 (0.47, 0.94)	0.023	310 (2328)	0.63 (0.44, 0.89)	0.009	333 (1078)	0.49 (0.28, 0.85)	0.011	167 (1078)
Difference	1.46 (1.11, 1.93)	0.007		1.67 (1.13, 2.48)	0.010		1.75 (1.19, 2.58)	0.005		2.09 (1.14, 3.84)	0.018
Group 1	1.11 (0.98, 1.26)	0.101	579 (2328)	1.10 (0.93, 1.31)	0.266	319 (2328)	1.04 (0.89, 1.23)	0.622	333 (1078)	0.96 (0.76, 1.21)	0.720	167 (1078)
Group 4	0.78 (0.67, 0.90)	0.001	579 (2328)	0.73 (0.60, 0.89)	0.002	319 (2328)	0.76 (0.63, 0.93)	0.007	333 (1078)	0.72 (0.55, 0.96)	0.025	167 (1078)
Difference	1.31 (1.11, 1.54)	0.001		1.37 (1.09, 1.72)	0.007		1.27 (1.02, 1.58)	0.034		1.25 (0.91, 1.73)	0.168

“Group 1” and “Group 4” refer to groups of haplotypes as previously defined in a previous publication [9]. Valine at position 11, the VKA haplotype and “group 1” haplotypes have previously been shown to be associated with the highest risk of susceptibility to RA [5]. Conversely, serine at position 11, the SEA haplotype and “group 4” haplotypes have been shown to be associated with the lowest risk [9]. Results are displayed as hazard ratios (HR) with 95% confidence intervals. The total number (n) of deaths is also displayed alongside the total number (n) of patients included in each analysis (in brackets). All models have been adjusted for cardiovascular risk factors namely; gender, hypertension and obesity. HR was not adjusted for other amino acids/haplotypes/groups. “Difference”: the difference in HR was calculated by the linear combination of the two HR obtained from a bivariate analysis (both amino acids/haplotypes/groups included in the same model). This represents the risk of death for the carriage of the highest risk susceptibility amino acid/haplotype/group, compared to the lowest risk amino acid/haplotype/group

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