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Table 2 Association statistics between genetic polymorphisms located within the HLA-DRB1 gene and disease mortality

From: HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status

Amino acid/haplotype/group Inflammatory polyarthritis (IP) Rheumatoid arthritis (RA)
All-cause mortality Cardiovascular mortality All-cause mortality Cardiovascular mortality
Hazard ratio (95% CI) p value n Hazard ratio (95% CI) p value n Hazard ratio (95% CI) p value n Hazard ratio (95% CI) p value n
Valine 11 1.16 (1.03, 1.30) 0.015 643 (2514) 1.10 (0.93, 1.30) 0.255 343 (2514) 1.10 (0.95, 1.28) 0.217 367 (1160) 0.96 (0.77, 1.19) 0.699 189 (1160)
Serine 11 0.83 (0.75, 0.94) 0.003 643 (2514) 0.82 (0.70, 0.96) 0.016 343 (2514) 0.83 (0.71, 0.97) 0.022 367 (1160) 0.86 (0.69, 1.07) 0.177 189 (1160)
Difference 1.26 (1.09, 1.45) 0.001   1.23 (1.01, 1.49) 0.038   1.22 (1.01, 1.47) 0.035   1.08 (0.83, 1.41) 0.559  
VKA haplotype 1.15 (0.99, 1.34) 0.073 579 (2328) 1.16 (0.94, 1.43) 0.158 310 (2328) 1.14 (0.94, 1.38) 0.190 333 (1078) 1.05 (0.79, 1.40) 0.715 167 (1078)
SEA haplotype 0.76 (0.59, 0.96) 0.024 579 (2328) 0.67 (0.47, 0.94) 0.023 310 (2328) 0.63 (0.44, 0.89) 0.009 333 (1078) 0.49 (0.28, 0.85) 0.011 167 (1078)
Difference 1.46 (1.11, 1.93) 0.007   1.67 (1.13, 2.48) 0.010   1.75 (1.19, 2.58) 0.005   2.09 (1.14, 3.84) 0.018  
Group 1 1.11 (0.98, 1.26) 0.101 579 (2328) 1.10 (0.93, 1.31) 0.266 319 (2328) 1.04 (0.89, 1.23) 0.622 333 (1078) 0.96 (0.76, 1.21) 0.720 167 (1078)
Group 4 0.78 (0.67, 0.90) 0.001 579 (2328) 0.73 (0.60, 0.89) 0.002 319 (2328) 0.76 (0.63, 0.93) 0.007 333 (1078) 0.72 (0.55, 0.96) 0.025 167 (1078)
Difference 1.31 (1.11, 1.54) 0.001   1.37 (1.09, 1.72) 0.007   1.27 (1.02, 1.58) 0.034   1.25 (0.91, 1.73) 0.168  
  1. “Group 1” and “Group 4” refer to groups of haplotypes as previously defined in a previous publication [9]. Valine at position 11, the VKA haplotype and “group 1” haplotypes have previously been shown to be associated with the highest risk of susceptibility to RA [5]. Conversely, serine at position 11, the SEA haplotype and “group 4” haplotypes have been shown to be associated with the lowest risk [9]. Results are displayed as hazard ratios (HR) with 95% confidence intervals. The total number (n) of deaths is also displayed alongside the total number (n) of patients included in each analysis (in brackets). All models have been adjusted for cardiovascular risk factors namely; gender, hypertension and obesity. HR was not adjusted for other amino acids/haplotypes/groups. “Difference”: the difference in HR was calculated by the linear combination of the two HR obtained from a bivariate analysis (both amino acids/haplotypes/groups included in the same model). This represents the risk of death for the carriage of the highest risk susceptibility amino acid/haplotype/group, compared to the lowest risk amino acid/haplotype/group