Fig. 4

Sparse partial least squares discriminant analysis (sPLS-DA) contribution to component 2. Serum samples were obtained from osteoarthritis (OA)-obese (n=10) and OA-non obese (n=10) individuals and analyzed by sPLS-DA. Contribution of the 23 proteins in component 2; the plots display the loading weight and indicate the class (OA-obese, [blue]; OA-non obese, [orange]; control, [gray]) for which the selected protein has a maximal mean value. The negative value indicates contributions higher in the OA-obese compared to the OA-non obese group, and positive number higher values in the OA-non obese. ADIPOQ, adiponectin; APOA1, apolipoprotein A-I; APOC1, apolipoprotein C-I; APOL1, apolipoprotein L1; DBH, dopamine beta hydroxylase; F12, coagulation factor XII; GP1BA, platelet glycoprotein Ib alpha chain; GPX3, glutathione peroxidase 3; HPR, haptoglobin-related protein; IGHD, Ig delta chain C region; IGFALS, insulin-like growth factor-binding protein complex acid labile subunit; IGLV2-14, Ig lambda chain V-II region TOG; IGLV4-69, Ig lambda variable 4-69; IGKV2-24, Ig kappa variable 2-24; IGLV2-23, Ig lambda chain V-II region NEI; IGKV3-15, Ig kappa chain V-III region POM; IGLV3-21, Ig lambda chain V-III region LOI; IGHV3OR16-12, Ig Heavy Variable 3/OR16-12 (Non-Functional); PON1, serum paraoxonase/arylesterase 1; PROC, vitamin K-dependent protein C; SERPINA6, corticosteroid-binding globulin; SERPINA3, alpha-1-antichymotrypsin; SERPINC1, antithrombin-III