Fig. 3

Arithmetic mean (SD) serum concentration of TCZ vs time profiles following TCZ IV 7 mg/kg Q4W in period 1 and TCZ IV 6 mg/kg Q4W in period 2, linear scale. Three patients received a sixth dose at week 20 in period 1. To align their end-of-period profile with those of the other patients, their week 16 data have been excluded from this plot. Only samples at predose and end of infusion were collected after the first, third, and fourth doses in each period. IV, intravenous; Q4W, every 4 weeks; SD, standard deviation; TCZ, tocilizumab