| Biological process | FDR | Molecular function | FDR |
---|---|---|---|---|
D/N | ||||
 Increased | Cellular response to vitamin k | 0.0282 | Fibronectin binding | 0.00012 |
Negative regulation of smooth muscle cell-matrix adhesion | 0.0282 | Proteoglycan binding | 2.03E−06 | |
UDP-glucuronate biosynthetic process | 0.0418 | Collagen binding | 1.08E−06 | |
Positive regulation of substrate-dependent cell migration, cell attachment to substrate | 0.0418 | Laminin binding | 0.04 | |
Negative regulation of plasminogen activation | 0.005 | Lipoprotein particle binding | 0.04 | |
 Decreased | Positive regulation of cell proliferation by vegf-activated pdgf receptor signaling pathway | 0.0029 | Procollagen-lysine 5-dioxygenase activity | 0.0066 |
Esophagus smooth muscle contraction | 0.0383 | Phosphodiesterase i activity | 0.0213 | |
Hydroxylysine biosynthetic process | 0.0383 | Platelet-derived growth factor binding | 0.00028 | |
Glomerular capillary formation | 0.0093 | Extracellular matrix structural constituent conferring tensile strength | 2.89E−10 | |
Peptidyl-lysine hydroxylation | 0.0153 | Low-density lipoprotein particle binding | 0.0159 | |
IC/N | ||||
 Increased | Actin filament fragmentation | 0.0023 | Peroxiredoxin activity | 0.00033 |
Helper t cell extravasation | 0.0151 | Thioredoxin peroxidase activity | 0.0108 | |
Cellular hyperosmotic salinity response | 0.0151 | Copper chaperone activity | 0.0108 | |
Positive regulation of establishment of protein localization to telomere | 2.99E−06 | Extracellular matrix constituent conferring elasticity | 0.0027 | |
CRD-mediated mRNA stabilization | 0.0037 | Threonine-type endopeptidase activity | 1.35E−06 | |
 Decreased | Collagen fibril organization | 4.85E−05 | Extracellular matrix structural constituent conferring tensile strength | 1.31E−07 |
Chondroitin sulfate proteoglycan biosynthetic process | 0.0053 | Heparan sulfate proteoglycan binding | 0.0126 | |
Chondroitin sulfate biosynthetic process | 0.0275 | Insulin-like growth factor binding | 0.00021 | |
Protein hydroxylation | 0.0301 | Extracellular matrix structural constituent | 3.48E−09 | |
Chondroitin sulfate proteoglycan metabolic process | 0.0025 | Proteoglycan binding | 0.0131 | |
ICD/N | ||||
 Increased | Actin filament fragmentation | 0.0031 | Peroxiredoxin activity | 0.00041 |
Fumarate metabolic process | 0.0188 | Threonine-type endopeptidase activity | 5.16E−12 | |
Helper t cell extravasation | 0.0188 | Thioredoxin peroxidase activity | 0.0143 | |
Protein unfolding | 0.0188 | Copper chaperone activity | 0.0143 | |
Cellular hyperosmotic salinity response | 0.0188 | Extracellular matrix constituent conferring elasticity | 0.004 | |
 Decreased | Hydroxylysine biosynthetic process | 0.0346 | Procollagen-lysine 5-dioxygenase activity | 0.0021 |
Peptidyl-lysine hydroxylation | 0.0112 | Insulin-like growth factor ii binding | 0.0145 | |
pdgf receptor-beta signaling pathway | 0.0112 | Extracellular matrix structural constituent conferring tensile strength | 3.20E−08 | |
Type b pancreatic cell proliferation | 0.0137 | Insulin-like growth factor i binding | 0.0242 | |
Basement membrane assembly | 0.0137 | Platelet-derived growth factor binding | 0.0291 | |
ICD/IC | ||||
 Increased | Negative regulation of plasminogen activation | 0.0011 | Threonine-type endopeptidase activity | 1.11E−07 |
Viral translational termination-reinitiation | 0.0126 | Peptide disulfide oxidoreductase activity | 0.0031 | |
Proteasomal ubiquitin-independent protein catabolic process | 4.16E−08 | S100 protein binding | 0.0041 | |
Modulation of age-related behavioral decline | 0.0033 | Fibroblast growth factor binding | 0.0136 | |
Negative regulation of dendritic cell apoptotic process | 0.0224 | Low-density lipoprotein particle receptor binding | 0.0153 | |
 Decreased | Hydroxylysine biosynthetic process | 0.0235 | Heparan sulfate proteoglycan binding | 0.0021 |
Gonadotrophin-releasing hormone neuronal migration to the hypothalamus | 0.0345 | CXCR chemokine receptor binding | 0.0478 | |
Positive regulation of cell proliferation by vegf-activated platelet-derived growth factor receptor signaling pathway | 0.0345 | Fibronectin binding | 0.0088 | |
Formaldehyde catabolic process | 0.0345 | Extracellular matrix structural constituent conferring tensile strength | 0.0096 | |
Facioacoustic ganglion development | 0.0345 | Laminin binding | 0.0105 |