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Table 1 Demographic and clinical data of participants according to their Kellgren-Lawrence grade

From: Metabolomics with severity of radiographic knee osteoarthritis and early phase synovitis in middle-aged women from the Iwaki Health Promotion Project: a cross-sectional study

  KL 0 KL 1 KL 2 KL 3 KL 4 p-value
Number of participants 271 187 79 45 14  
Age (years) 45.9 ± 13.6 57.3 ± 11.6 66.0 ± 11.4 71.9 ± 7.5 69.6 ± 9.0 < 0.001
BMI (kg/m2) 21.2 ± 3.2 22.8 ± 3.5 23.3 ± 3.8 25.3 ± 4.3 25.5 ± 5.4 < 0.001
Muscle volume (kg) 6.3 ± 0.7 6.2 ± 0.9 5.9 ± 0.8 5.9 ± 0.7 6.0 ± 0.6 < 0.001
hs-CRP (mg/dL) 0.06 ± 0.16 0.06 ± 0.13 0.06 ± 0.13 0.08 ± 0.16 0.06 ± 0.11 0.918
MMP-3 (mg/mL) 36.4 ± 18.7 37.3 ± 14.5 34.0 ± 11.9 38.1 ± 13.1 42.6 ± 12.5 0.319
IL-6 (pg/mL) 1.8 ± 6.3 1.0 ± 1.2 1.2 ± 1.1 1.2 ± 0.7 0.7 ± 0.4 0.408
HA (ng/mL) 48.6 ± 64.7 46.8 ± 49.7 45.5 ± 50.4 80.3 ± 86.0 40.7 ± 93.2 0.016
  1. Data are presented as the mean ± standard deviation and were compared using analysis of variance tests. The muscle volume refers to that of the right thigh and lower leg
  2. BMI body mass index, HA hyaluronic acid, hs-CRP high-sensitive C-reactive protein, IL-6 interleukin-6, KL Kellgren-Lawrence grade, MMP-3 matrix metalloproteinase 3