Fig. 1

Schematic overview of the experimental design. A In experiment (Exp) 1, the fatigue resistance and intracellular events were evaluated under control conditions (CNT) and after induction of experimental autoimmune myosistis (EAM) with and without subsequent high-intensity interval training (HIIT). HIIT was initiated the day after the last immunization to induce EAM and was performed with electrical stimulation of the left leg (EAM + HIIT) every other day for a total of 14 sessions. The right leg served as a non-training EAM control. In Exp 2, cellular signaling that underlies the HIIT-induced physiological adaptations was investigated after an acute single bout of HIIT. B Typical torque traces of a HIIT session