Responder group comparisons | Training/test set comparisons | Total (n = 775) | |||||
---|---|---|---|---|---|---|---|
Good responders (n = 510) | Poor responders (n = 265) | p-value* | Training set (n = 365) | Test set (n = 410) | p-value* | ||
Age, years | 50 (40, 58) (n = 371) | 50 (41, 57) (n = 237) | 0.66 | 50 (40, 57) | 50 (40, 59) (n = 243) | 0.40 | 50 (40, 58) (n = 608) |
Female, n (%) | 402 (78.8) | 215 (81.1) | 0.45 | 286 (78.4) | 331 (80.7) | 0.41 | 617 (79.6) |
Race: White, n (%) | 269 (52.7) | 157 (59.2) | 0.08 | 239 (65.5) | 187 (45.6) | < 0.001 | 426 (55) |
DAS28-ESR | 6.5 (5.9, 7.2) | 7.6 (6.9, 8.1) | < 0.001 | 7.1 (6.4, 7.8) | 6.7 (6.0, 7.4) | < 0.001 | 6.9 (6.2, 7.6) |
TJC28 | 14 (9, 20) | 21 (16, 26) | < 0.001 | 18 (12, 24) | 15 (10, 22) | < 0.001 | 16 (11, 23) |
SJC28 | 10.5 (7, 15) | 15 (11, 22) | < 0.001 | 13 (9, 19) | 11 (8, 16) | < 0.001 | 12 (8, 17) |
ESR, mm/h | 42.5 (31, 64) | 63 (42, 88) | < 0.001 | 57 (38, 81) | 42.5 (32, 64) | < 0.001 | 49 (34, 74.5) |
PtGA | 65 (50, 79) | 76 (61, 88) | < 0.001 | 71 (55, 83) | 67 (50, 82) | < 0.001 | 69 (52, 83) |
CRP, mg/L | 2.3 (0.9, 5.0) (n = 509) | 3.1 (1.4, 7.2) (n = 263) | < 0.001 | 2.4 (1.3, 4.4) (n = 362) | 2.7 (0.8, 8.9) | 0.25 | 2.5 (1.0, 6.2) (n = 772) |
PhGA | 66 (52, 76) (n = 509) | 72 (62, 83) | < 0.001 | 70 (56, 80) (n = 364) | 68 (53.2, 77) | 0.034 | 68.5 (55, 78) (n = 774) |
RF positive, n (%) | 463 (91.1) (n = 508) | 241 (90.9) | 0.93 | 329 (90.1) | 375 (91.9) (n = 408) | 0.39 | 704 (91.1) (n = 773) |
ACPA positive, n (%) | 447 (88.3) (n = 506) | 230 (87.8) (n = 262) | 0.82 | 325 (90.3) (n = 360) | 352 (86.3) (n = 408) | 0.09 | 677 (88.2) (n = 768) |
Glucocorticoids use, n (%) | 124 (46.4) (n = 267) | 56 (36.4) (n = 154) | 0.044 | 87 (48.9) (n = 178) | 93 (38.3) (n = 243) | 0.030 | 180 (42.8) (n = 421) |
HAQ | 1.6 (1.1, 2.0) (n = 463) | 2.0 (1.6, 2.4) (n = 238) | < 0.001 | 2.0 (1.6, 2.2) (n = 294) | 1.6 (1.1, 2.0) (n = 407) | < 0.001 | 1.8 (1.2, 2.1) (n = 701) |
RA duration, months | 3.7 (1.5, 7.9) | 5.3 (2.2, 13.4) | < 0.001 | 6.9 (3.6, 17.2) | 2.2 (1.0, 5.7) | < 0.001 | 4.1 (1.7, 9.2) |
Good Responders, n (%) | 199 (54.5) | 311 (75.9) | < 0.001 |