Whole cohort (n=225) | |||||
---|---|---|---|---|---|
mean ± SD or n and (%) | 95% confidence interval | n* | |||
Characteristics | |||||
Female sex, no [%] | 183 | 81.3 % | |||
Age [years] | 58.14 | ± | 12.95 | 56.44 to 59.84 | 225 |
Height [cm] | 166.13 | ± | 08.63 | 165.00 to 167.26 | 225 |
Weight [kg] | 70.85 | ± | 15.80 | 68.78 to 72.93 | 225 |
Systolic blood pressure [mmHg] | 133.00 | ± | 21.14 | 130.19 to 135.82 | 219 |
Diastolic blood pressure [mmHg] | 76.02 | ± | 10.93 | 74.57 to 77.48 | 219 |
Heart rate at rest [/min] | 75.63 | ± | 12.36 | 73.46 to 77.80 | 127 |
Type of systemic sclerosis | 225 | ||||
Limited cutaneous SSc [%] | 152 | 67.6% | |||
Diffuse cutaneous SSc [%] | 54 | 24.0% | |||
Early SSc | 19 | 8.4% | |||
Duration SSc [days] | 3420.54 | ± | 3325.72 | 2980.65 to 3860.42 | 222 |
SSc characteristics | |||||
Modified Rodnan skin score | 12 | ± | 10 | 10 to 13 | 160 |
Digital ulcers | 76 | 33.9% | 224 | ||
WHO-FC, no [%] | |||||
I | 54 | 24.0% | 54 | ||
II | 108 | 48.0% | 108 | ||
III | 59 | 26.3% | 53 | ||
IV | 4 | 1.8% | 4 | ||
Lung function | |||||
Vital capacity max [l] | 2.96 | ± | 0.95 | 2.84 to 3.09 | 221 |
Forced expiratory volume in one second [l] | 2.35 | ± | 0.78 | 2.25 to 2.45 | 222 |
Total lung capacity [l] | 5.05 | ± | 1.29 | 4.88 to 5.22 | 221 |
Diffusion capacity of the lung for carbon monoxide SB [%] | 57.50 | ± | 18.27 | 55.02 to 59.98 | 211 |
Diffusion capacity of the lung for carbon monoxide/VA [%] | 72.51 | ± | 19.90 | 69.82 to 75.20 | 213 |
Mixed venous oxygen saturation [%] | 72.13 | ± | 12.93 | 69.36 to 74.90 | 86 |
Laboratory | |||||
N-terminal pro-brain natriuretic peptide [ng/l] | 374.31 | ± | 718.49 | 274.12 to 474.49 | 200 |
C-reactive protein [mg/l] | 6.95 | ± | 9.42 | 5.7 to 8.19 | 222 |
Troponin T [μg/l] | 125 | ± | 11.62 | 8.45 to 12.57 | 125 |
Glomerular filtration rate [ml/min/1.73m2] | 85.81 | ± | 26.36 | 82.2 to 89.43 | 207 |
Creatinine [mg/dl] | 0.88 | ± | 0.88 | 0.76 to 1.0 | 222 |
6-minute walking distance [meters] | 439.93 | ± | 96.18 | 426.72 to 453.14 | 206 |
Echocardiography | |||||
Right atrial area [cm2] | 12.38 | ± | 3.73 | 11.88 to 12.88 | 214 |
Right ventricular area [cm2] | 14.81 | ± | 3.66 | 14.33 to 15.30 | 218 |
Systolic pulmonary arterial pressure [mmHg] | 32.10 | ± | 13.43 | 30.30 to 33.90 | 216 |
Tricuspid annular plane systolic excursion [mm] | 23.93 | ± | 4.45 | 23.34 to 24.53 | 218 |
Right ventricular fractional area change [%] | 0.71 | ± | 0.32 | 0.63 to 0.78 | 69 |
Tissue Doppler imaging tissue velocity S | 14 | ± | 3 | 13 to 14 | 182 |
Increase of systolic pulmonary arterial pressure during exercise [mmHg] | 25.78 | ± | 10.65 | 23.80 to 27.76 | 114 |
Right heart catheter | |||||
Mean pulmonary arterial pressure [mmHg] | 20.41 | ± | 8.43 | 19.31 to 21.52 | 225 |
Cardiac output [l/min] | 5.39 | ± | 1.42 | 5.20 to 5.57 | 225 |
Pulmonary arterial wedge pressure [mmHg] | 9.39 | ± | 4.18 | 8.84 to 9.94 | 225 |
Pulmonary vascular resistance [WU] | 2.22 | ± | 1.73 | 1.99 to 2.45 | 225 |
Pulmonary arterial compliance [ml/mmHg] | 4.41 | ± | 2.31 | 4.08 to 4.74 | 195 |
RV pulmonary vascular reserve [mmHg/l/min] | 7.79 | ± | 43.62 | 2.06 to 13.52 | 225 |
Cardiac index [l/min/m2] | 3.08 | ± | 0.78 | 2.98 to 3.18 | 225 |
Cardiac index increase during exercise [l/min/m2] | 2.78 | ± | 1.59 | 2.57 to 2.98 | 225 |
Peak cardiac index [l/min/m2] | 5.86 | ± | 1.69 | 5.63 to 6.08 | 225 |
Right ventricular pump function | 221 | ||||
Normal | 199 | 90.0% | |||
Mild impairment | 11 | 5.0% | |||
Moderate impairment | 4 | 1.8% | |||
Severe impairment | 7 | 3.2% |