Table 2 Baseline characteristics of the RHYTHM full cohort and subset
From: Prospective changes in diastolic function in patients with rheumatoid arthritis
Characteristic | Full cohort baseline (n=158) | Longitudinal cohort at baseline (n=60) | Longitudinal cohort at follow-up (n=60) |
|---|---|---|---|
Demographic | |||
Age | 54±12 | 53 ±11 | 57±12 |
Female (158) | 133 (84) | 49 (82) | 49 (82) |
Race/ethnicity (150) | |||
White | 54 (36) | 24 (40) | |
Black | 27 (18) | 10 (17) | |
Hispanic | 62 (41.3) | 24 (40) | |
Other | 7 (4.67) | 2 (3.3) | |
RA characteristics | |||
Disease duration (years) | 10.7 ± 11.9 | 8.3 ± 9.6 | ND |
CDAI | 17.5 ± 12.4 | 16.7 ± 12.3 | 13.6 ± 12 |
DAS28-CRP | 3.71 ± 1.36 | 3.26 ± 1.1 | 3.1 ± 1.3** |
RF or anti-CCP (% positive) (145) | 107 (73.3) | 41 (69.5) | ND |
CRP per mg/liter | 5.1 ± 7.5 | 6.1 ± 9.4 | 7.1 ± 18.8* |
IL-6 (log) per mg/liter | 1.1 ± 1.2 | 1.2 ± 1.1 | 0.84 ± 1.1* |
BNP per pg/mL | 21.8 ± 17.8 | 21.7 ± 20.6 | ND |
Troponin-I (pg/mL) | 1.08 ± 1.56 | 0.90 ± 1.3 | ND |
Galectin-3 (ng/mL) | 9.56 ± 4.86 | 9.64 ± 5.6 | ND |
RA medication | |||
No DMARDs | 15 (9.6) | 3 (5) | 8 (13) |
MTX (156) | 102 (65) | 46 (77) | 25 (42)** |
Targeted DMARDs (156) | 64 (41) | 25 (42) | 35 (58) |
TNF inhibitor | 45 (29) | 19 (30) | 21 (35) |
Prednisone (156) | 47 (30.1) | 15 (25) | 4 (7.3) |
CV risk factors | |||
Current smoker (155) | 16 (10.3) | 6 (10) | 4 (7.1) |
Ever smoker (155) | 60 (38.7) | 22 (36.7) | ND |
SBP mm/Hg (149) | 118 ±16.7 | 116 ±16.8 | 124 ±17.0** |
BP medications (156) | 53 (34) | 12 (20) | 13 (23) |
Statin (156) | 23 (14.7) | 12 (20) | 13 (22.8) |
Total cholesterol (145) | 194 ± 37.9 | 187 ± 33 | 186.3 ±30.8 |
LDL (145) | 112 ± 33.1 | 107.2 ± 29.9 | 103.6 ± 27.5 |
Diabetes#(149) | 13 (7.9) | 4 (7.4) | 8 (14.3) |
PET/CT cardiac measures | |||
CAC score (157) | |||
0 | 106 (67.9) | 44 (75) | ND |
≥ 100 | 27 (17.2) | 10 (17) | ND |
Mean myocardial SUV, mean (149) | 2.54±2.04 | 2.7±2.2 | ND |
Max myocardial SUV, mean (148) | 3.95±3.29 | 4.5±3.6 | ND |
Myocardial flow reserve (111) | 2.92±0.69 | 2.87± 0.62 | ND |