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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study

Fig. 3

Comparison of observed pegloticase concentrations in the current study (MIRROR OL, pegloticase + methotrexate co-therapy) and in a simulated PK profile of prior phase 3 trials (pegloticase monotherapy). Circles represent the observed data in MIRROR OL with non-responders in red and responders in blue. Simulated monotherapy pegloticase concentration over time is shown as the median concentration (black line) with 90% confidence intervals (gray-shaded area). The simulation was modeled using the time elapsed from the start of each infusion, pooling data from all 12 infusions administered to phase 3 pivotal trial participants. Values below the limit of quantitation were imputed as 0.3 μg/ml (dotted line)

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Arthritis Research & Therapy

ISSN: 1478-6362

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