Fig. 4

Effects of abatacept on cytokine/chemokine production in monocytes stimulated with the ACPA immune complex. Peripheral blood samples were obtained from 17 patients with rheumatoid arthritis and used. The concentrations of IL-1β, IL-6, TNF-α, IL-8, and CCL2 were measured by multiplex bead arrays. Statistical comparisons between the two groups were made using the Mann–Whitney U test