Fig. 3

In post-traumatic mice models, bilobalide reduced cartilage erosion. A, B Representative images of articular cartilage stained with safranin O and fast green. The Osteoarthritis Research Society International score was quantified. C, D Representative images of articular cartilage stained with hematoxylin and eosin. The ratio of hyaline cartilage to calcified cartilage was measured. E, F Representative images of articular cartilage stained with toluidine blue. Quantification of the summed score. The values represent the mean ± standard deviation. Each in vivo experiment was repeated six times or more. Statistically, significant differences between the indicated groups are indicated by ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, or ^****p < 0.0001