Fig. 7From: CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145/HGF axis in osteoarthritisThe schematic diagram of circPRKCH regulation mechanism in OA. CircPRKCH promoted c-MET phosphorylation and activated the HGF/c-MET signaling pathway by directly binding miR-145 to disinhibit HGF, leading to ECM degradation and OA occurrenceBack to article page