Table 3 Comparison of clinical items in mucous membrane/eye and ENT manifestation between patients with and without HP
| Â | Total AAV | Newly diagnosed AAV | Relapsed AAV | ||||||
|---|---|---|---|---|---|---|---|---|---|
HP (n = 30) | Non-HP (n = 633) | p-values | HP (n = 20) | Non-HP (n = 538) | p-values | HP (n = 10) | Non-HP (n = 95) | p-values | |
Manifestation | |||||||||
 Mucous membranes/eyes, number (%) | |||||||||
  Mouth ulcers | 0 | 9 (1.4) | 0.999 | 0 | 9 (1.7) | – | – | 0 | – |
  Genital ulcers | 0 | 0 | – | 0 | 0 | – | – | 0 | – |
  Adnexal inflammation | 0 | 0 | – | 0 | 0 | – | – | 0 | – |
  Significant proptosis | 0 | 5 (0.8) | 1 | 0 | 2 (0.4) | 1 | 0 | 3 (3.2) | 0.999 |
  Scleritis/episcleritis | 5 (17) | 29 (4.6) | 0.015 | 3 (15) | 26 (4.8) | 0.079 | 2 (20) | 3 (3.2) | 0.070 |
  Conjunctivitis/blepharitis/keratitis | 0 | 7 (1.1) | 0.999 | 0 | 7 (1.3) | 0.999 | 0 | 0 | – |
  Blurred vision | 2 (6.7) | 10 (1.6) | 0.099 | 1 (5) | 8 (1.5) | 0.282 | 1 (10) | 2 (2.1) | 0.262 |
  Sudden visual loss | 6 (20) | 6 (0.9) | < 0.0001 | 2 (10) | 3 (0.5) | 0.012 | 4 (40) | 3 (3.2) | 0.001 |
  Uveitis | 0 | 4 (0.6) | 1 | 0 | 5 (0.9) | 0.999 | 0 | 0 | – |
  Retinal changes (vasculitis, thrombosis/exudate/hemorrhage) | 0 | 5 (0.8) | 0.999 | 0 | 3 (0.5) | 0.999 | 0 | 1 (1.1) | 1 |
 ENT, number (%) | |||||||||
  Bloody nasal discharge/crusts/ulcers/granulomata | 2 (6.7) | 46 (7.2) | 0.999 | 1 (5) | 38 (7.1) | 0.999 | 1 (10) | 8 (8) | 0.999 |
  Paranasal sinus involvement | 7 (23) | 108 (17) | 0.334 | 5 (17) | 76 (17) | 0.371 | 2 (20) | 15 (16) | 0.663 |
  Subglottic stenosis | 0 | 1 (0.2) | 1 | 0 | 0 | – | 0 | 1 (1.1) | 1 |
  Conductive hearing loss | 11 (37) | 42 (6.6) | < 0.0001 | 9 (45) | 40 (7.4) | < 0.0001 | 2 (20) | 2 (2.1) | 0.044 |
  Sensorineural hearing loss | 7 (23) | 25 (3.9) | 0.0003 | 5 (25) | 20 (3.7) | 0.001 | 2 (20) | 5 (5.3) | 0.133 |