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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Identification of HBEGF+ fibroblasts in the remission of rheumatoid arthritis by integrating single-cell RNA sequencing datasets and bulk RNA sequencing datasets

Fig. 2

EGF signaling pathway in RA synovium. a Heatmap showing the EGF signaling interaction scores between each cluster in RA synovium. b Ligand (HBEGF) and receptor (EGFR) of EGF signaling pathway are shown in dot plots. c Other ligands (AREG, BTC, EGF, EREG, and TGFA) of EGF signaling pathway shown in dot plots. d 6708 cells from OA meniscus and cartilage at UMAP and receptor (EGFR) of EGF signaling pathway are shown in dot plot (e). f Boxplot showing expression of ligands (HBEGF, AREG, BTC, EGF, EREG, and TGFA) using bulk RNA-seq profiles of healthy joint synovium (n = 26), RA joint synovium (n = 53), and OA joint synovium (n = 33). Significance determined by Student’s t test (P = 0.0003). e Boxplot showing HBEGF expression of bulk RNA-seq profiles from RA synovium before and after triple DMARD treatment (n=19). Significance determined by Student’s paired t test (P = 0.05433)

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Arthritis Research & Therapy

ISSN: 1478-6362

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