Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample

Ma, Canchen; Aitken, Dawn; Wu, Feitong; Squibb, Kathryn; Cicuttini, Flavia; Jones, Graeme

doi:10.1186/s13075-022-02907-6

Arthritis Research & Therapy

Table 3 Standardized beta-coefficients for the associations of site-specific osteophyte and joint space narrowing scores with HRpQCT measures (per SD) stratified by 1st CMC, distal, and proximal sites (N = 201)

From: Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample

	Osteophyte scores			Joint space narrowing scores
	1st CMC β (95% CI)^a	Distal site β (95% CI)^b	Proximal site β (95% CI)^b	1st CMC β (95% CI)^a	Distal site β (95% CI)^b	Proximal site β (95% CI)^b
Areas and density
Total bone area	0.35 (0.26, 0.44)	0.07 (0.05, 0.10)	0.21 (0.17, 0.24)	0.38 (0.28, 0.48)	0.03 (0.01, 0.04)	0.09 (0.07, 0.10)
Cortical area	0.54 (0.38, 0.71)	0.14 (0.01, 0.28)	0.16 (0.01, 0.31)	0.65 (0.48, 0.83)	0.06 (−0.01, 0.14)	0.03 (−0.03, 0.10)
Trabecular area	0.35 (0.26, 0.45)	0.06 (0.02, 0.10)	0.20 (0.15, 0.26)	0.36 (0.26, 0.47)	0.01 (−0.01, 0.04)	0.09 (0.06, 0.11)
Total vBMD	0.06 (−0.01, 0.13)	−0.03 (−0.19, 0.12)	−0.48 (−0.69, −0.27)	0.08 (0.01, 0.16)	−0.03 (−0.12, 0.06)	−0.26 (−0.35, −0.17)
Cortical vBMD	0.07 (−0.02, 0.17)	−0.04 (−0.20, 0.12)	−0.49 (−0.69, −0.30)	0.07 (−0.04, 0.17)	−0.06 (−0.15, 0.03)	−0.24 (−0.33, −0.16)
Trabecular vBMD	0.06 (−0.02, 0.14)	−0.10 (−0.24, 0.03)	−0.53 (−0.70, −0.36)	0.09 (0.01, 0.18)	−0.09 (−0.17, −0.01)	−0.28 (−0.35, −0.21)
Cortical bone microarchitecture
Cortical thickness	0.23 (0.14, 0.32)	0.09 (−0.11, 0.30)	−0.17 (−0.43, 0.09)	0.29 (0.19, 0.38)	0.02 (−0.10, 0.13)	−0.16 (−0.27, −0.04)
Cortical perimeter	0.26 (0.19, 0.34)	0.09 (0.06, 0.12)	0.31 (0.26, 0.37)	0.26 (0.17, 0.35)	0.05 (0.03, 0.06)	0.15 (0.13, 0.17)
Trabecular microarchitecture
Tb.BV/TV^c	0.07 (−0.01, 0.15)	−0.10 (−0.24, 0.03)	−0.53 (−0.70, −0.36)	0.10 (0.01, 0.18)	−0.09 (−0.17, −0.01)	−0.28 (−0.35, −0.21)
Trabecular number	−0.03 (−0.19, 0.12)	−0.27 (−0.45, −0.09)	−0.58 (−0.85, −0.31)	0.01 (−0.16, 0.18)	−0.27 (−0.36, −0.16)	−0.34 (−0.46, −0.22)
Trabecular thickness	0.10 (0.05, 0.16)	0.11 (−0.03, 0.25)	−0.04 (−0.25, 0.16)	0.11 (0.05, 0.17)	0.11 (0.03, 0.19)	−0.03 (−0.12, 0.06)
Trabecular separation	0.10 (−0.09, 0.26)	0.23 (0.06, 0.41)	0.64 (0.41, 0.87)	0.05 (−0.14, 0.24)	0.27 (0.17, 0.37)	0.33 (0.23, 0.43)
Tb.1/N.SD^c	0.23 (0.01, 0.45)	0.29 (0.15, 0.43)	0.46 (0.27, 0.66)	0.17 (−0.08, 0.41)	0.21 (0.13, 0.29)	0.22 (0.13, 0.30)

Beta coefficients represent a 1 unit increase in osteophyte/JSN score per SD change in HRpQCT measure. Bold denotes statistical significance. Distal site: distal 2nd distal interphalangeal joint, distal 2nd proximal interphalangeal joint. Proximal site: proximal 2nd distal interphalangeal joint, and proximal 2nd proximal interphalangeal joint
SD standard deviation, CI confidence interval, CMC carpometacarpal joint, vBMD volumetric bone density, Tb.BV/TV trabecular bone volume fraction, Tb.1/N.SD inhomogeneity of trabecular network
^aMultivariable linear regression adjusting for age, sex, and BMI
^bMixed-effects model including fixed effects for age, sex, BMI, and random intercepts for ROIs
^cParameters were calculated using the derived measurement method

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