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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype

Fig. 5

Top upregulated genes for each subpopulation. Genes expressed in chondrocytes from oligoarticular JIA were COL6A3 (65.1%), COL3A1 (66.8%), and MMP2 (85.5%) (A). Genes expressed in the greatest percentage in chondrocytes from ETB JIA were NEAT1 (99.2%), PCOLCE (83.7%), and MEG3 (86.7%) (A). Genes expressed in the greatest percentage in chondrocytes from polyarticular JIA were CCDC80 (99.7%), COMP (72.8%), and CHI3L1 (93.9%) (A). Genes expressed in fibroblasts from oligoarticular JIA were MYL12A (74.5%), IGFBP7 (82.9%), and LOX (77.5%) (B). Genes expressed in fibroblasts from ETB JIA were CCND1 (74%), FTH1 (99.8%), and FTL (99.7%) (B). Genes expressed in fibroblasts from polyarticular JIA were IFI27 (81.1%), MFAP5 (81.8%), and S100A4 (93.8%) (B). Genes expressed in smooth muscle cell-like from oligoarticular JIA FLS were CAV1 (67.5%), FTL (99.9%), and TMSB4X (98.8%) (C). Genes expressed in smooth muscle cell-like from extend-to-be JIA FLS were SERPINE2 (86.7%), CCND1 (79.7%), and GREM1 (58.3%) (C). Genes expressed in smooth muscle cell-like cells from polyarticular JIA were AKAP12 (62%), CAV1 (80.2%), and S100A4 (72.2%) (C). p-values were < 0.01

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Arthritis Research & Therapy

ISSN: 1478-6362

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